Detailed information of TA system TA115730

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2057602..2058118
• Replicon: chromosome
• Accession: NZ_CP034336
• Organism: Enterobacter asburiae strain CAV1043

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EI562_RS10375
• Protein ID: WP_023310189.1
• Coordinates: 2057602..2057886 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: EI562_RS10380
• Protein ID: WP_008501400.1
• Coordinates: 2057876..2058118 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EI562_RS10360	2052816..2054459	+	1644	WP_023310192.1	alpha,alpha-phosphotrehalase	-
EI562_RS10365	2054836..2056974	+	2139	WP_023310191.1	anaerobic ribonucleoside-triphosphate reductase	-
EI562_RS10370	2057134..2057598	+	465	WP_023310190.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
EI562_RS10375	2057602..2057886	-	285	WP_023310189.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EI562_RS10380	2057876..2058118	-	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EI562_RS10385	2058196..2060106	-	1911	WP_023310188.1	BglG family transcription antiterminator	-
EI562_RS10390	2060129..2061265	-	1137	WP_023310187.1	lactonase family protein	-
EI562_RS10395	2061381..2062121	-	741	WP_023310186.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10908.82 Da
• Isoelectric Point: 10.2016

>T115730 WP_023310189.1 NZ_CP034336:c2057886-2057602 [Enterobacter asburiae]
MTYELAFDPRALKEWCKLGQTVKDLFKKKLADVLVNPRVESARLHGLPDCYKIKLRTQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T115730 NZ_CP034336:c2057886-2057602 [Enterobacter asburiae]
ATGACTTATGAACTGGCATTTGACCCGAGGGCGTTAAAGGAGTGGTGCAAGCTGGGGCAGACTGTAAAAGACCTGTTTAA
GAAGAAACTTGCGGACGTGCTGGTGAACCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTGCCGGATTGCTACAAAATAA
AACTCAGAACGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
CGAGAGAAATCAGCCGTTTATCATGATGCTAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT115730 WP_008501400.1 NZ_CP034336:c2058118-2057876 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT115730 NZ_CP034336:c2058118-2057876 [Enterobacter asburiae]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTACTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACGATTAGCGACA
GCGAAGATGCGCTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: V3EXX3