Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1506324..1506944 Replicon chromosome
Accession NZ_CP034336
Organism Enterobacter asburiae strain CAV1043

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag EI562_RS07805 Protein ID WP_008499287.1
Coordinates 1506726..1506944 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag EI562_RS07800 Protein ID WP_008499288.1
Coordinates 1506324..1506698 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EI562_RS07790 1501450..1502643 + 1194 WP_023310601.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EI562_RS07795 1502666..1505812 + 3147 WP_023310600.1 multidrug efflux RND transporter permease subunit -
EI562_RS07800 1506324..1506698 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
EI562_RS07805 1506726..1506944 + 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
EI562_RS07810 1507150..1507701 + 552 WP_023310599.1 maltose O-acetyltransferase -
EI562_RS07815 1507819..1508286 + 468 WP_023310598.1 hypothetical protein -
EI562_RS07820 1508258..1509718 - 1461 WP_023310597.1 PLP-dependent aminotransferase family protein -
EI562_RS07825 1509820..1510530 + 711 WP_023310596.1 GNAT family N-acetyltransferase -
EI562_RS07830 1510527..1510667 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EI562_RS07835 1510670..1510930 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T115729 WP_008499287.1 NZ_CP034336:1506726-1506944 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T115729 NZ_CP034336:1506726-1506944 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTCGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAGCTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT115729 WP_008499288.1 NZ_CP034336:1506324-1506698 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT115729 NZ_CP034336:1506324-1506698 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References