Detailed information of TA system TA115727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 18542..19185
• Replicon: plasmid unnamed2
• Accession: NZ_CP034330
• Organism: Tabrizicola piscis strain K13M18

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EI545_RS21055
• Protein ID: WP_125327922.1
• Coordinates: 18784..19185 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EI545_RS21050
• Protein ID: WP_125327921.1
• Coordinates: 18542..18784 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EI545_RS21030	13659..14951	+	1293	WP_125327917.1	AAA family ATPase	-
EI545_RS21035	14963..16066	+	1104	WP_125327918.1	ParB N-terminal domain-containing protein	-
EI545_RS21040	16096..17259	-	1164	WP_125327919.1	ATP-binding protein	-
EI545_RS21045	17429..18472	-	1044	WP_125327920.1	tyrosine-type recombinase/integrase	-
EI545_RS21050	18542..18784	+	243	WP_125327921.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EI545_RS21055	18784..19185	+	402	WP_125327922.1	type II toxin-antitoxin system VapC family toxin	Toxin
EI545_RS21060	19419..20345	-	927	WP_125327923.1	LysR family transcriptional regulator	-
EI545_RS21065	20496..21455	+	960	WP_125327924.1	MBL fold metallo-hydrolase	-
EI545_RS21070	21591..22055	+	465	WP_125327925.1	nuclear transport factor 2 family protein	-
EI545_RS21075	22073..22690	+	618	WP_125327926.1	pyridoxamine 5'-phosphate oxidase family protein	-
EI545_RS21080	22836..23465	+	630	WP_125327933.1	glutathione S-transferase	-
EI545_RS21085	23620..24168	-	549	WP_125327927.1	peroxidase-related enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..29404	29404

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-50)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14513.46 Da
• Isoelectric Point: 4.8606

>T115727 WP_125327922.1 NZ_CP034330:18784-19185 [Tabrizicola piscis]
MYLLDTNVISAVRRPDRAPQVAAWLRGKAEGDLFLSVITIGEIERGICAQDRQNPAFAADLRSWVDRTVQVFSDRILPFT
AEDARIWGRLSQEIGHGSADLMIAATALARGATVVTGNVDDFRATGVALENPF

Nucleotide

• Length: 402 bp

>T115727 NZ_CP034330:18784-19185 [Tabrizicola piscis]
ATGTATCTGCTGGATACCAACGTGATCTCTGCGGTGCGTCGCCCCGACCGCGCCCCGCAGGTTGCCGCCTGGCTGCGTGG
CAAAGCGGAAGGCGATCTGTTTCTGAGCGTCATCACGATTGGAGAGATCGAGCGCGGCATCTGCGCGCAAGACAGGCAGA
ACCCTGCCTTTGCGGCAGACCTGCGGTCCTGGGTTGATCGGACGGTGCAGGTGTTCTCCGACCGGATCCTGCCGTTCACG
GCTGAAGATGCCCGTATCTGGGGACGCCTGAGCCAGGAGATCGGTCATGGTAGCGCGGACCTGATGATCGCCGCTACCGC
TCTTGCACGAGGCGCCACGGTGGTGACCGGCAATGTCGACGATTTCCGAGCCACCGGCGTTGCGCTGGAAAATCCGTTCT
AA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8836.96 Da
• Isoelectric Point: 7.3202

>AT115727 WP_125327921.1 NZ_CP034330:18542-18784 [Tabrizicola piscis]
MWTLQDAKNRFSSVVEAALAGRPQEVTRRGKAAVVVLSAEAYHRLVAEAAEHRESFADHLLAFPGGEFERLSARPRDAAF

Nucleotide

• Length: 243 bp

>AT115727 NZ_CP034330:18542-18784 [Tabrizicola piscis]
ATGTGGACGCTGCAAGATGCGAAAAACCGCTTTTCTTCCGTGGTGGAGGCCGCTCTGGCTGGTCGACCGCAGGAAGTGAC
CCGGCGCGGCAAGGCGGCGGTGGTCGTGCTGTCGGCTGAGGCATACCACAGGCTTGTCGCTGAAGCGGCCGAGCATCGCG
AGAGCTTTGCGGACCATCTTCTGGCCTTTCCGGGGGGCGAGTTTGAACGCTTGTCTGCGCGCCCGCGCGATGCAGCATTC
TGA