Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4990912..4991956 Replicon chromosome
Accession NZ_CP034321
Organism Klebsiella pneumoniae strain 33

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag EJB01_RS24740 Protein ID WP_000019186.1
Coordinates 4990912..4991460 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag EJB01_RS24745 Protein ID WP_000287252.1
Coordinates 4991483..4991956 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJB01_RS24705 4986124..4986675 - 552 WP_000515860.1 hypothetical protein -
EJB01_RS24710 4986719..4986919 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
EJB01_RS24715 4987010..4987684 + 675 WP_000859462.1 LexA family transcriptional repressor -
EJB01_RS24720 4988165..4988713 + 549 WP_009008284.1 hypothetical protein -
EJB01_RS24725 4988779..4989603 + 825 WP_001753751.1 DUF2303 family protein -
EJB01_RS24730 4989820..4990572 + 753 WP_001701368.1 hypothetical protein -
EJB01_RS24735 4990609..4990878 + 270 WP_001093912.1 pyocin activator PrtN family protein -
EJB01_RS24740 4990912..4991460 - 549 WP_000019186.1 hypothetical protein Toxin
EJB01_RS24745 4991483..4991956 - 474 WP_000287252.1 SocA family protein Antitoxin
EJB01_RS24750 4992427..4992915 - 489 WP_002884935.1 cupin domain-containing protein -
EJB01_RS24755 4993165..4993680 + 516 WP_002884931.1 zinc uptake transcriptional repressor Zur -
EJB01_RS24760 4993776..4993985 - 210 WP_004151747.1 CsbD family protein -
EJB01_RS24765 4994051..4994200 + 150 WP_004219133.1 hypothetical protein -
EJB01_RS24770 4994220..4995536 - 1317 WP_004151748.1 MATE family efflux transporter DinF -
EJB01_RS24775 4995606..4996214 - 609 WP_002884822.1 transcriptional repressor LexA -
EJB01_RS24780 4996337..4996705 - 369 WP_002884819.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4947208..4999257 52049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T115723 WP_000019186.1 NZ_CP034321:c4991460-4990912 [Klebsiella pneumoniae]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T115723 NZ_CP034321:c4991460-4990912 [Klebsiella pneumoniae]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT115723 WP_000287252.1 NZ_CP034321:c4991956-4991483 [Klebsiella pneumoniae]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT115723 NZ_CP034321:c4991956-4991483 [Klebsiella pneumoniae]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References