Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4730706..4731222 Replicon chromosome
Accession NZ_CP034321
Organism Klebsiella pneumoniae strain 33

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag EJB01_RS23405 Protein ID WP_004178374.1
Coordinates 4730706..4730990 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EJB01_RS23410 Protein ID WP_002886901.1
Coordinates 4730980..4731222 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJB01_RS23380 4726102..4726410 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
EJB01_RS23385 4726495..4726668 + 174 WP_032103426.1 hypothetical protein -
EJB01_RS23390 4726671..4727414 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
EJB01_RS23395 4727771..4729909 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
EJB01_RS23400 4730238..4730702 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EJB01_RS23405 4730706..4730990 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJB01_RS23410 4730980..4731222 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EJB01_RS23415 4731300..4733210 - 1911 WP_015959311.1 BglG family transcription antiterminator -
EJB01_RS23420 4733233..4734387 - 1155 WP_004178372.1 lactonase family protein -
EJB01_RS23425 4734454..4735194 - 741 WP_015959310.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T115721 WP_004178374.1 NZ_CP034321:c4730990-4730706 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T115721 NZ_CP034321:c4730990-4730706 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT115721 WP_002886901.1 NZ_CP034321:c4731222-4730980 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT115721 NZ_CP034321:c4731222-4730980 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References