Detailed information of TA system TA115705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 832168..832780
• Replicon: chromosome
• Accession: NZ_CP034315
• Organism: Streptococcus agalactiae strain TFJ0901

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: DNK17_RS04525
• Protein ID: WP_000384860.1
• Coordinates: 832168..832503 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: DNK17_RS04530
• Protein ID: WP_000259017.1
• Coordinates: 832493..832780 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DNK17_RS04495	827366..828007	+	642	WP_000591144.1	hypothetical protein	-
DNK17_RS04505	828307..829182	+	876	WP_000421240.1	hypothetical protein	-
DNK17_RS04510	829218..829652	+	435	WP_001220479.1	hypothetical protein	-
DNK17_RS04515	829969..831225	+	1257	WP_000122836.1	plasmid recombination protein	-
DNK17_RS04520	831393..831863	+	471	WP_000130119.1	hypothetical protein	-
DNK17_RS04525	832168..832503	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DNK17_RS04530	832493..832780	-	288	WP_000259017.1	hypothetical protein	Antitoxin
DNK17_RS04535	833274..833564	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
DNK17_RS04540	833666..834073	+	408	WP_000749954.1	hypothetical protein	-
DNK17_RS04545	834073..834633	+	561	WP_001865562.1	hypothetical protein	-
DNK17_RS04550	834606..835286	+	681	WP_001865565.1	hypothetical protein	-
DNK17_RS04555	835271..835657	+	387	WP_000259069.1	hypothetical protein	-
DNK17_RS04560	835691..835972	+	282	WP_000052407.1	hypothetical protein	-
DNK17_RS04580	836815..837675	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	824199..833041	8842

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T115705 WP_000384860.1 NZ_CP034315:c832503-832168 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T115705 NZ_CP034315:c832503-832168 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT115705 WP_000259017.1 NZ_CP034315:c832780-832493 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT115705 NZ_CP034315:c832780-832493 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6