Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 1408294..1408853 | Replicon | chromosome |
| Accession | NZ_CP034305 | ||
| Organism | Vibrio parahaemolyticus strain 20151116002-3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | EHC68_RS07340 | Protein ID | WP_031856368.1 |
| Coordinates | 1408294..1408572 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U2ZGZ5 |
| Locus tag | EHC68_RS07345 | Protein ID | WP_005497249.1 |
| Coordinates | 1408569..1408853 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EHC68_RS07295 | 1403373..1403462 | + | 90 | WP_077281740.1 | DUF3265 domain-containing protein | - |
| EHC68_RS07300 | 1403498..1404106 | + | 609 | WP_025796196.1 | pyridoxamine 5'-phosphate oxidase family protein | - |
| EHC68_RS07305 | 1404737..1404826 | + | 90 | WP_079878894.1 | DUF3265 domain-containing protein | - |
| EHC68_RS07310 | 1404853..1405284 | + | 432 | WP_031856582.1 | DUF2513 domain-containing protein | - |
| EHC68_RS07315 | 1405271..1405402 | + | 132 | WP_079882753.1 | DUF3265 domain-containing protein | - |
| EHC68_RS07320 | 1405440..1406039 | + | 600 | WP_031856598.1 | hypothetical protein | - |
| EHC68_RS07325 | 1406174..1406704 | + | 531 | WP_085576757.1 | hypothetical protein | - |
| EHC68_RS07330 | 1407331..1407687 | + | 357 | WP_017449618.1 | hypothetical protein | - |
| EHC68_RS07335 | 1407702..1407794 | + | 93 | WP_072600995.1 | DUF3265 domain-containing protein | - |
| EHC68_RS07340 | 1408294..1408572 | - | 279 | WP_031856368.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| EHC68_RS07345 | 1408569..1408853 | - | 285 | WP_005497249.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| EHC68_RS07350 | 1409064..1409489 | + | 426 | WP_031856367.1 | hypothetical protein | - |
| EHC68_RS07355 | 1410251..1410526 | + | 276 | WP_031856366.1 | antibiotic biosynthesis monooxygenase | - |
| EHC68_RS07365 | 1410688..1411317 | + | 630 | WP_031856365.1 | hypothetical protein | - |
| EHC68_RS07370 | 1411337..1411429 | + | 93 | WP_004748931.1 | DUF3265 domain-containing protein | - |
| EHC68_RS07375 | 1411461..1411766 | + | 306 | WP_021453216.1 | hypothetical protein | - |
| EHC68_RS07380 | 1411923..1412411 | + | 489 | WP_031856291.1 | DUF523 domain-containing protein | - |
| EHC68_RS07385 | 1412429..1412518 | + | 90 | Protein_1301 | DUF3265 domain-containing protein | - |
| EHC68_RS07390 | 1412619..1413026 | + | 408 | WP_025502308.1 | DUF4476 domain-containing protein | - |
| EHC68_RS07400 | 1413645..1413773 | + | 129 | WP_168192500.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1314407..1445556 | 131149 | |
| - | inside | Integron | - | - | 1314931..1439037 | 124106 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10915.56 Da Isoelectric Point: 4.4548
>T115703 WP_031856368.1 NZ_CP034305:c1408572-1408294 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAANKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPEAANKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T115703 NZ_CP034305:c1408572-1408294 [Vibrio parahaemolyticus]
ATGATTTTGTGGGAAGAAGAGTCCCTCAACGATCGCGAAAAGATCTTTGAGTTTCTCTACGACTTCAACCCCGAAGCTGC
TAACAAAACCGACGATATTATTGAAGCAAAAGTTGAGAACCTTTTAGAGCAACCTCATATGGGAGTCCAGCGTGACGGAA
TTAGAGGGCGATTGCTCATTATTCCTGAGATTTCGATGATTGTTTCCTACTGGGTTGAAGGTGATATCATTCGAGTTATG
CGTGTGCTACACCAAAAACAAAAATTCCCAACGGACTAA
ATGATTTTGTGGGAAGAAGAGTCCCTCAACGATCGCGAAAAGATCTTTGAGTTTCTCTACGACTTCAACCCCGAAGCTGC
TAACAAAACCGACGATATTATTGAAGCAAAAGTTGAGAACCTTTTAGAGCAACCTCATATGGGAGTCCAGCGTGACGGAA
TTAGAGGGCGATTGCTCATTATTCCTGAGATTTCGATGATTGTTTCCTACTGGGTTGAAGGTGATATCATTCGAGTTATG
CGTGTGCTACACCAAAAACAAAAATTCCCAACGGACTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10913.25 Da Isoelectric Point: 9.1865
>AT115703 WP_005497249.1 NZ_CP034305:c1408853-1408569 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
Download Length: 285 bp
>AT115703 NZ_CP034305:c1408853-1408569 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACGAAGCGACTAGCCCAACAAATGGCTGAAAGCCAAGGCAGAAC
ACTAAGTGATGCTTGTCGTGAACTGACTGAGCAACTAGCTGACCAACAGAGAAAGACTTTATCTCACGACGCATGGTTAA
CTGAACAAGTTAACTTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGACCATGAGTCAGCTAAATCTCGT
ATGGCCGAGCGTAAAGCTAAAATCCGTAACCGAGGCAAATTATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACGAAGCGACTAGCCCAACAAATGGCTGAAAGCCAAGGCAGAAC
ACTAAGTGATGCTTGTCGTGAACTGACTGAGCAACTAGCTGACCAACAGAGAAAGACTTTATCTCACGACGCATGGTTAA
CTGAACAAGTTAACTTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGACCATGAGTCAGCTAAATCTCGT
ATGGCCGAGCGTAAAGCTAAAATCCGTAACCGAGGCAAATTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|