Detailed information of TA system TA115703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1408294..1408853
• Replicon: chromosome
• Accession: NZ_CP034305
• Organism: Vibrio parahaemolyticus strain 20151116002-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EHC68_RS07340
• Protein ID: WP_031856368.1
• Coordinates: 1408294..1408572 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2ZGZ5
• Locus tag: EHC68_RS07345
• Protein ID: WP_005497249.1
• Coordinates: 1408569..1408853 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC68_RS07295	1403373..1403462	+	90	WP_077281740.1	DUF3265 domain-containing protein	-
EHC68_RS07300	1403498..1404106	+	609	WP_025796196.1	pyridoxamine 5'-phosphate oxidase family protein	-
EHC68_RS07305	1404737..1404826	+	90	WP_079878894.1	DUF3265 domain-containing protein	-
EHC68_RS07310	1404853..1405284	+	432	WP_031856582.1	DUF2513 domain-containing protein	-
EHC68_RS07315	1405271..1405402	+	132	WP_079882753.1	DUF3265 domain-containing protein	-
EHC68_RS07320	1405440..1406039	+	600	WP_031856598.1	hypothetical protein	-
EHC68_RS07325	1406174..1406704	+	531	WP_085576757.1	hypothetical protein	-
EHC68_RS07330	1407331..1407687	+	357	WP_017449618.1	hypothetical protein	-
EHC68_RS07335	1407702..1407794	+	93	WP_072600995.1	DUF3265 domain-containing protein	-
EHC68_RS07340	1408294..1408572	-	279	WP_031856368.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EHC68_RS07345	1408569..1408853	-	285	WP_005497249.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EHC68_RS07350	1409064..1409489	+	426	WP_031856367.1	hypothetical protein	-
EHC68_RS07355	1410251..1410526	+	276	WP_031856366.1	antibiotic biosynthesis monooxygenase	-
EHC68_RS07365	1410688..1411317	+	630	WP_031856365.1	hypothetical protein	-
EHC68_RS07370	1411337..1411429	+	93	WP_004748931.1	DUF3265 domain-containing protein	-
EHC68_RS07375	1411461..1411766	+	306	WP_021453216.1	hypothetical protein	-
EHC68_RS07380	1411923..1412411	+	489	WP_031856291.1	DUF523 domain-containing protein	-
EHC68_RS07385	1412429..1412518	+	90	Protein_1301	DUF3265 domain-containing protein	-
EHC68_RS07390	1412619..1413026	+	408	WP_025502308.1	DUF4476 domain-containing protein	-
EHC68_RS07400	1413645..1413773	+	129	WP_168192500.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1314407..1445556	131149
	-	inside	Integron	-	-	1314931..1439037	124106

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10915.56 Da
• Isoelectric Point: 4.4548

>T115703 WP_031856368.1 NZ_CP034305:c1408572-1408294 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAANKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T115703 NZ_CP034305:c1408572-1408294 [Vibrio parahaemolyticus]
ATGATTTTGTGGGAAGAAGAGTCCCTCAACGATCGCGAAAAGATCTTTGAGTTTCTCTACGACTTCAACCCCGAAGCTGC
TAACAAAACCGACGATATTATTGAAGCAAAAGTTGAGAACCTTTTAGAGCAACCTCATATGGGAGTCCAGCGTGACGGAA
TTAGAGGGCGATTGCTCATTATTCCTGAGATTTCGATGATTGTTTCCTACTGGGTTGAAGGTGATATCATTCGAGTTATG
CGTGTGCTACACCAAAAACAAAAATTCCCAACGGACTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10913.25 Da
• Isoelectric Point: 9.1865

>AT115703 WP_005497249.1 NZ_CP034305:c1408853-1408569 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL

Nucleotide

• Length: 285 bp

>AT115703 NZ_CP034305:c1408853-1408569 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACGAAGCGACTAGCCCAACAAATGGCTGAAAGCCAAGGCAGAAC
ACTAAGTGATGCTTGTCGTGAACTGACTGAGCAACTAGCTGACCAACAGAGAAAGACTTTATCTCACGACGCATGGTTAA
CTGAACAAGTTAACTTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGACCATGAGTCAGCTAAATCTCGT
ATGGCCGAGCGTAAAGCTAAAATCCGTAACCGAGGCAAATTATGA

Structures

Antitoxin

• AlphaFold DB: U2ZGZ5