Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 2124926..2125473 | Replicon | chromosome |
| Accession | NZ_CP034298 | ||
| Organism | Vibrio parahaemolyticus strain 20160303005-1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A7Z2MSV0 |
| Locus tag | EHC69_RS10640 | Protein ID | WP_025527253.1 |
| Coordinates | 2124926..2125228 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | EHC69_RS10645 | Protein ID | WP_005448240.1 |
| Coordinates | 2125216..2125473 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EHC69_RS10580 | 2120073..2120129 | - | 57 | WP_114867976.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10590 | 2120792..2121376 | - | 585 | WP_201452316.1 | cold shock and DUF1294 domain-containing protein | - |
| EHC69_RS10595 | 2121420..2121512 | - | 93 | WP_008081753.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10600 | 2121533..2122120 | - | 588 | WP_114867662.1 | hypothetical protein | - |
| EHC69_RS10605 | 2122280..2122630 | - | 351 | WP_042762920.1 | RidA family protein | - |
| EHC69_RS10610 | 2122779..2123075 | - | 297 | WP_114867663.1 | hypothetical protein | - |
| EHC69_RS10615 | 2123241..2123645 | - | 405 | WP_021705403.1 | DUF1801 domain-containing protein | - |
| EHC69_RS10620 | 2123800..2124321 | - | 522 | WP_114867664.1 | GNAT family N-acetyltransferase | - |
| EHC69_RS10625 | 2124351..2124443 | - | 93 | WP_140341327.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10630 | 2124469..2124753 | - | 285 | WP_103195693.1 | nucleotide pyrophosphohydrolase | - |
| EHC69_RS10635 | 2124798..2124890 | - | 93 | WP_080285085.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10640 | 2124926..2125228 | - | 303 | WP_025527253.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EHC69_RS10645 | 2125216..2125473 | - | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| EHC69_RS10650 | 2125555..2125644 | - | 90 | WP_071652537.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10655 | 2126165..2126269 | - | 105 | WP_193234862.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10660 | 2126272..2126889 | - | 618 | WP_114867666.1 | hypothetical protein | - |
| EHC69_RS10665 | 2126912..2127034 | - | 123 | WP_077281732.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10670 | 2127472..2128023 | - | 552 | WP_114867667.1 | VRR-NUC domain-containing protein | - |
| EHC69_RS10675 | 2128042..2128173 | - | 132 | WP_114867668.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10680 | 2128534..2128689 | - | 156 | WP_079757872.1 | DUF3265 domain-containing protein | - |
| EHC69_RS10685 | 2128679..2128984 | - | 306 | WP_025787418.1 | hypothetical protein | - |
| EHC69_RS10690 | 2129056..2129145 | - | 90 | WP_072833118.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2052855..2139950 | 87095 | |
| - | inside | Integron | - | - | 2054735..2138239 | 83504 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11640.53 Da Isoelectric Point: 4.8951
>T115699 WP_025527253.1 NZ_CP034298:c2125228-2124926 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T115699 NZ_CP034298:c2125228-2124926 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT115699 WP_005448240.1 NZ_CP034298:c2125473-2125216 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT115699 NZ_CP034298:c2125473-2125216 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAGATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAGATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z2MSV0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A432DGX8 |