Detailed information of TA system TA115695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1630838..1631354
• Replicon: chromosome
• Accession: NZ_CP034295
• Organism: Vibrio parahaemolyticus strain 20140829008-1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EHC66_RS24380
• Protein ID: WP_029865924.1
• Coordinates: 1630838..1631107 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EHC66_RS24385
• Protein ID: WP_029865959.1
• Coordinates: 1631100..1631354 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC66_RS24340	1625968..1626333	+	366	WP_031428075.1	hypothetical protein	-
EHC66_RS24345	1626677..1627615	-	939	WP_031428077.1	DMT family transporter	-
EHC66_RS24350	1627719..1628600	+	882	WP_108653693.1	LysR family transcriptional regulator	-
EHC66_RS24355	1628804..1629292	-	489	WP_108653692.1	DUF523 domain-containing protein	-
EHC66_RS24360	1629410..1629946	-	537	WP_108653691.1	ClbS/DfsB family four-helix bundle protein	-
EHC66_RS24365	1630014..1630082	-	69	WP_080254664.1	DUF3265 domain-containing protein	-
EHC66_RS24370	1630157..1630405	+	249	WP_025611568.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EHC66_RS24375	1630395..1630685	+	291	WP_108653690.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EHC66_RS24380	1630838..1631107	-	270	WP_029865924.1	Txe/YoeB family addiction module toxin	Toxin
EHC66_RS24385	1631100..1631354	-	255	WP_029865959.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EHC66_RS24390	1631456..1631548	-	93	WP_140321407.1	DUF3265 domain-containing protein	-
EHC66_RS24395	1631663..1632631	+	969	WP_159404068.1	IS30-like element ISVa6 family transposase	-
EHC66_RS24400	1633097..1633246	-	150	WP_108654761.1	DUF3265 domain-containing protein	-
EHC66_RS24405	1633221..1633688	-	468	WP_108654760.1	NUDIX domain-containing protein	-
EHC66_RS24410	1633794..1634786	-	993	WP_108654759.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1595150..1642793	47643
	-	flank	IS/Tn	-	-	1631855..1632631	776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10628.98 Da
• Isoelectric Point: 7.9816

>T115695 WP_029865924.1 NZ_CP034295:c1631107-1630838 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRVDDTNRLVYAVDDQVI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T115695 NZ_CP034295:c1631107-1630838 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAGCGTTTACTGTCGTGGACTGATGACGCTTGGGACGACTACCTGTATTGGCAAACTCAAGACAAAAA
AACACTCAAGCGTATCAATAAACTTATCAATGATGTTAAACGTTCTCCATTTGAGGGTATCGGTAAACCTGAGCCATTGA
AAGAGAACTTATCTGGTTTTTGGTCCCGTCGTGTTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAGGTCATA
ACGATAATCTCGTGTCGTTACCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9467.63 Da
• Isoelectric Point: 5.0623

>AT115695 WP_029865959.1 NZ_CP034295:c1631354-1631100 [Vibrio parahaemolyticus]
MRIVSFTEARNALKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT115695 NZ_CP034295:c1631354-1631100 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGCTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGTCGTGATTCTGAAGATGCTGTGGTTATGTCCTTAGATTACTACAATAGCCTTATGGAGACAGTGCACT
TACTACGCTCTCCTCAAAACGCTGAACACTTAAACCGTTCTATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG