Detailed information of TA system TA115693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1388647..1389196
• Replicon: chromosome
• Accession: NZ_CP034294
• Organism: Vibrio parahaemolyticus strain 20140829008-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EHC66_RS07085
• Protein ID: WP_159404083.1
• Coordinates: 1388647..1388946 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A347UQT2
• Locus tag: EHC66_RS07090
• Protein ID: WP_005442033.1
• Coordinates: 1388954..1389196 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC66_RS07055	1384232..1384879	+	648	WP_159404077.1	glutathione S-transferase	-
EHC66_RS07060	1385047..1385544	+	498	WP_159404078.1	DinB family protein	-
EHC66_RS07065	1385709..1386476	+	768	WP_159404079.1	FRG domain-containing protein	-
EHC66_RS07070	1386939..1387133	+	195	WP_193237469.1	DUF3265 domain-containing protein	-
EHC66_RS07075	1387160..1387780	+	621	WP_159404081.1	hypothetical protein	-
EHC66_RS07080	1387934..1388476	+	543	WP_193237468.1	GNAT family N-acetyltransferase	-
EHC66_RS07085	1388647..1388946	-	300	WP_159404083.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHC66_RS07090	1388954..1389196	-	243	WP_005442033.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EHC66_RS07095	1389436..1389948	+	513	WP_159404084.1	hypothetical protein	-
EHC66_RS07100	1389984..1390952	-	969	WP_159404068.1	IS30-like element ISVa6 family transposase	-
EHC66_RS07105	1391018..1391170	+	153	WP_159408277.1	DUF3265 domain-containing protein	-
EHC66_RS07115	1392111..1392203	+	93	WP_140256639.1	DUF3265 domain-containing protein	-
EHC66_RS26500	1392608..1392751	+	144	WP_180793999.1	DUF3265 domain-containing protein	-
EHC66_RS07125	1392796..1393080	+	285	WP_021452995.1	hypothetical protein	-
EHC66_RS07130	1393088..1393198	+	111	WP_080721571.1	DUF3265 domain-containing protein	-
EHC66_RS07135	1393344..1393634	+	291	WP_025787412.1	TM2 domain-containing protein	-
EHC66_RS07140	1393716..1393805	+	90	Protein_1254	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1333692..1410042	76350
	-	inside	Integron	-	-	1362114..1407583	45469

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11543.16 Da
• Isoelectric Point: 8.0336

>T115693 WP_159404083.1 NZ_CP034294:c1388946-1388647 [Vibrio parahaemolyticus]
MQKNKYKLSNLAQSHLRKVKDYTVENFSELQWRNYKDTLLSGFQMLADNPDLGRSCDEIYPNGFFFPIGKHTAYFIKEDD
FILVVGVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T115693 NZ_CP034294:c1388946-1388647 [Vibrio parahaemolyticus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAGACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACTCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGACTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTTTTTCCCGATTGGAAAACACACAGCTTATTTCATCAAAGAAGATGAC
TTTATCTTAGTCGTTGGTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9047.26 Da
• Isoelectric Point: 5.6926

>AT115693 WP_005442033.1 NZ_CP034294:c1389196-1388954 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT115693 NZ_CP034294:c1389196-1388954 [Vibrio parahaemolyticus]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTGAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGATGGTGAAAGCTTTCTGAACTCGCTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A347UQT2