Detailed information of TA system TA115692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1342264..1342811
• Replicon: chromosome
• Accession: NZ_CP034294
• Organism: Vibrio parahaemolyticus strain 20140829008-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EHC66_RS06640
• Protein ID: WP_140060746.1
• Coordinates: 1342509..1342811 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: EHC66_RS06635
• Protein ID: WP_005448240.1
• Coordinates: 1342264..1342521 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC66_RS06595	1337315..1337407	+	93	WP_074531776.1	DUF3265 domain-containing protein	-
EHC66_RS06600	1337845..1337934	+	90	WP_075984317.1	DUF3265 domain-containing protein	-
EHC66_RS06605	1338457..1339380	+	924	WP_020838889.1	zinc dependent phospholipase C family protein	-
EHC66_RS06610	1339377..1339775	+	399	WP_023623455.1	hypothetical protein	-
EHC66_RS06615	1339923..1340432	+	510	WP_069523627.1	AAA family ATPase	-
EHC66_RS06620	1340568..1340981	+	414	WP_020838843.1	hypothetical protein	-
EHC66_RS06625	1341007..1341975	-	969	WP_159404068.1	IS30-like element ISVa6 family transposase	-
EHC66_RS06635	1342264..1342521	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EHC66_RS06640	1342509..1342811	+	303	WP_140060746.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHC66_RS06645	1342847..1342939	+	93	WP_077673135.1	DUF3265 domain-containing protein	-
EHC66_RS06655	1343886..1344056	+	171	Protein_1167	DUF3265 domain-containing protein	-
EHC66_RS26490	1344070..1344561	+	492	WP_025553544.1	hypothetical protein	-
EHC66_RS06660	1344593..1344685	+	93	WP_193237466.1	DUF3265 domain-containing protein	-
EHC66_RS06665	1344715..1345242	+	528	WP_159408084.1	hypothetical protein	-
EHC66_RS06670	1345683..1345823	+	141	WP_180761348.1	DUF3265 domain-containing protein	-
EHC66_RS06675	1345855..1346373	+	519	WP_193237467.1	GNAT family N-acetyltransferase	-
EHC66_RS06680	1346514..1346978	+	465	WP_159408085.1	GNAT family N-acetyltransferase	-
EHC66_RS06690	1347574..1347705	+	132	WP_158173963.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1333692..1410042	76350
	-	flank	IS/Tn	-	-	1341007..1341783	776
	-	inside	Integron	-	-	1334216..1358143	23927

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11592.48 Da
• Isoelectric Point: 4.8951

>T115692 WP_140060746.1 NZ_CP034294:1342509-1342811 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIVSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T115692 NZ_CP034294:1342509-1342811 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCGTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCGC
CTGAATTAGAACATCTAAGCTATCGTGAAGTTGTAGTTAATCCGTGCCGCGTTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGACTTGCGTAAGTTCCTATTGAGCAAGCAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT115692 WP_005448240.1 NZ_CP034294:1342264-1342521 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT115692 NZ_CP034294:1342264-1342521 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAAATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGCAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCGGATGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8