Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2700357..2702185 Replicon chromosome
Accession NZ_CP034289
Organism Vibrio parahaemolyticus strain 20140722001-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EHC64_RS13405 Protein ID WP_161613063.1
Coordinates 2700357..2701718 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EHC64_RS13410 Protein ID WP_029786578.1
Coordinates 2701703..2702185 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHC64_RS13380 2695464..2696378 - 915 WP_159408108.1 hypothetical protein -
EHC64_RS13385 2696675..2697595 - 921 WP_159408109.1 IS5 family transposase -
EHC64_RS13390 2698062..2698448 + 387 WP_159408110.1 transcriptional regulator -
EHC64_RS13395 2698531..2698821 - 291 Protein_2411 hypothetical protein -
EHC64_RS13400 2699069..2699860 + 792 WP_159408111.1 metallophosphoesterase -
EHC64_RS13405 2700357..2701718 + 1362 WP_161613063.1 type II toxin-antitoxin system HipA family toxin Toxin
EHC64_RS13410 2701703..2702185 + 483 WP_029786578.1 helix-turn-helix domain-containing protein Antitoxin
EHC64_RS13415 2702671..2702853 + 183 Protein_2415 lipase family protein -
EHC64_RS13420 2702984..2703547 - 564 WP_005455971.1 porin family protein -
EHC64_RS13425 2703946..2704836 + 891 WP_023623232.1 LysR family transcriptional regulator -
EHC64_RS13430 2704972..2706504 + 1533 WP_005464264.1 bifunctional GNAT family N-acetyltransferase/carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2670392..2704836 34444
- flank IS/Tn - - 2696675..2697595 920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51341.04 Da        Isoelectric Point: 4.8126

>T115687 WP_161613063.1 NZ_CP034289:2700357-2701718 [Vibrio parahaemolyticus]
MEELTVQAFLRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLTFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRVKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVSLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCLNLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T115687 NZ_CP034289:2700357-2701718 [Vibrio parahaemolyticus]
ATGGAAGAACTAACCGTACAAGCTTTTCTCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAATCACCCTGTCTCATTCTTTTTTGATGACATGGGTAAACCTGGATGGTTAACGTTTCTAGACGATATTATG
CCTAGTGGTGCTAGTAGACGATACTGGGTCAAACACCTGGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTATTGGTAACTTAAGAGTAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACAACAAAGAGGGGCAGCCGCA
GGTGGTGCAACTGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGCGGTTTCGATCATGGATCTGGTAGCGAAAA
AATATGGATTGACCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTGTGGCTTCCTCGATTTGATGTTCAAATTATTGAGCA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCTCTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
GAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTCGTAGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAAGTGTTATTACAAGAACTAGAGGTTACTGCAAGTAAATGCCTTAATTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17535.05 Da        Isoelectric Point: 10.8446

>AT115687 WP_029786578.1 NZ_CP034289:2701703-2702185 [Vibrio parahaemolyticus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT115687 NZ_CP034289:2701703-2702185 [Vibrio parahaemolyticus]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAACCCAAGACTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
AGATGTATCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AACCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References