Detailed information of TA system TA115686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1412631..1413180
• Replicon: chromosome
• Accession: NZ_CP034289
• Organism: Vibrio parahaemolyticus strain 20140722001-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EHC64_RS07265
• Protein ID: WP_159404083.1
• Coordinates: 1412631..1412930 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A347UQT2
• Locus tag: EHC64_RS07270
• Protein ID: WP_005442033.1
• Coordinates: 1412938..1413180 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC64_RS07235	1408216..1408863	+	648	WP_159404077.1	glutathione S-transferase	-
EHC64_RS07240	1409031..1409528	+	498	WP_159404078.1	DinB family protein	-
EHC64_RS07245	1409693..1410460	+	768	WP_159404079.1	FRG domain-containing protein	-
EHC64_RS07250	1410923..1411117	+	195	WP_193237469.1	DUF3265 domain-containing protein	-
EHC64_RS07255	1411144..1411764	+	621	WP_159404081.1	hypothetical protein	-
EHC64_RS07260	1411918..1412460	+	543	WP_193237468.1	GNAT family N-acetyltransferase	-
EHC64_RS07265	1412631..1412930	-	300	WP_159404083.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHC64_RS07270	1412938..1413180	-	243	WP_005442033.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EHC64_RS07275	1413420..1413932	+	513	WP_159404084.1	hypothetical protein	-
EHC64_RS07280	1413957..1414049	+	93	WP_079877499.1	DUF3265 domain-containing protein	-
EHC64_RS07285	1414687..1415118	-	432	WP_043038654.1	hypothetical protein	-
EHC64_RS07290	1415903..1416250	+	348	WP_031410908.1	hypothetical protein	-
EHC64_RS07295	1416403..1416936	+	534	WP_140104155.1	hypothetical protein	-
EHC64_RS07300	1417072..1417839	+	768	WP_159404085.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1375141..1430234	55093
	-	inside	Integron	-	-	1350338..1441359	91021

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11543.16 Da
• Isoelectric Point: 8.0336

>T115686 WP_159404083.1 NZ_CP034289:c1412930-1412631 [Vibrio parahaemolyticus]
MQKNKYKLSNLAQSHLRKVKDYTVENFSELQWRNYKDTLLSGFQMLADNPDLGRSCDEIYPNGFFFPIGKHTAYFIKEDD
FILVVGVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T115686 NZ_CP034289:c1412930-1412631 [Vibrio parahaemolyticus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAGACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACTCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGACTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTTTTTCCCGATTGGAAAACACACAGCTTATTTCATCAAAGAAGATGAC
TTTATCTTAGTCGTTGGTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9047.26 Da
• Isoelectric Point: 5.6926

>AT115686 WP_005442033.1 NZ_CP034289:c1413180-1412938 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT115686 NZ_CP034289:c1413180-1412938 [Vibrio parahaemolyticus]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTGAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGATGGTGAAAGCTTTCTGAACTCGCTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A347UQT2