Detailed information of TA system TA115682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1519935..1520451
• Replicon: chromosome
• Accession: NZ_CP034286
• Organism: Vibrio parahaemolyticus strain 20140624012-1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EHC70_RS23660
• Protein ID: WP_029865924.1
• Coordinates: 1519935..1520204 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EHC70_RS23665
• Protein ID: WP_029865959.1
• Coordinates: 1520197..1520451 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC70_RS23615	1515066..1515431	+	366	WP_031428075.1	hypothetical protein	-
EHC70_RS23620	1515775..1516713	-	939	WP_031428077.1	DMT family transporter	-
EHC70_RS23625	1516817..1517467	+	651	WP_159404361.1	LysR family transcriptional regulator	-
EHC70_RS23630	1517425..1517697	+	273	Protein_1334	hypothetical protein	-
EHC70_RS23635	1517901..1518389	-	489	WP_108653692.1	DUF523 domain-containing protein	-
EHC70_RS23640	1518507..1519043	-	537	WP_108653691.1	ClbS/DfsB family four-helix bundle protein	-
EHC70_RS23645	1519111..1519179	-	69	WP_080254664.1	DUF3265 domain-containing protein	-
EHC70_RS23650	1519254..1519502	+	249	WP_025611568.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EHC70_RS23655	1519492..1519782	+	291	WP_108653690.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EHC70_RS23660	1519935..1520204	-	270	WP_029865924.1	Txe/YoeB family addiction module toxin	Toxin
EHC70_RS23665	1520197..1520451	-	255	WP_029865959.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EHC70_RS23670	1520553..1520645	-	93	WP_140321407.1	DUF3265 domain-containing protein	-
EHC70_RS23675	1520760..1521728	+	969	WP_159404068.1	IS30-like element ISVa6 family transposase	-
EHC70_RS23680	1522194..1522343	-	150	WP_108654761.1	DUF3265 domain-containing protein	-
EHC70_RS23685	1522318..1522785	-	468	WP_108654760.1	NUDIX domain-containing protein	-
EHC70_RS23690	1522891..1523883	-	993	WP_108654759.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1484249..1531890	47641
	-	flank	IS/Tn	-	-	1520952..1521728	776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10628.98 Da
• Isoelectric Point: 7.9816

>T115682 WP_029865924.1 NZ_CP034286:c1520204-1519935 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRVDDTNRLVYAVDDQVI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T115682 NZ_CP034286:c1520204-1519935 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAGCGTTTACTGTCGTGGACTGATGACGCTTGGGACGACTACCTGTATTGGCAAACTCAAGACAAAAA
AACACTCAAGCGTATCAATAAACTTATCAATGATGTTAAACGTTCTCCATTTGAGGGTATCGGTAAACCTGAGCCATTGA
AAGAGAACTTATCTGGTTTTTGGTCCCGTCGTGTTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAGGTCATA
ACGATAATCTCGTGTCGTTACCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9467.63 Da
• Isoelectric Point: 5.0623

>AT115682 WP_029865959.1 NZ_CP034286:c1520451-1520197 [Vibrio parahaemolyticus]
MRIVSFTEARNALKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT115682 NZ_CP034286:c1520451-1520197 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGCTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGTCGTGATTCTGAAGATGCTGTGGTTATGTCCTTAGATTACTACAATAGCCTTATGGAGACAGTGCACT
TACTACGCTCTCCTCAAAACGCTGAACACTTAAACCGTTCTATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG