Detailed information of TA system TA115680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1345311..1345860
• Replicon: chromosome
• Accession: NZ_CP034285
• Organism: Vibrio parahaemolyticus strain 20140624012-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EHC70_RS06760
• Protein ID: WP_159404083.1
• Coordinates: 1345311..1345610 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A347UQT2
• Locus tag: EHC70_RS06765
• Protein ID: WP_005442033.1
• Coordinates: 1345618..1345860 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC70_RS06730	1340896..1341543	+	648	WP_159404077.1	glutathione S-transferase	-
EHC70_RS06735	1341711..1342208	+	498	WP_159404078.1	DinB family protein	-
EHC70_RS06740	1342373..1343140	+	768	WP_159404079.1	FRG domain-containing protein	-
EHC70_RS06745	1343603..1343797	+	195	WP_193237469.1	DUF3265 domain-containing protein	-
EHC70_RS06750	1343824..1344444	+	621	WP_159404081.1	hypothetical protein	-
EHC70_RS06755	1344598..1345140	+	543	WP_193237468.1	GNAT family N-acetyltransferase	-
EHC70_RS06760	1345311..1345610	-	300	WP_159404083.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHC70_RS06765	1345618..1345860	-	243	WP_005442033.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EHC70_RS06770	1346100..1346612	+	513	WP_159404084.1	hypothetical protein	-
EHC70_RS06775	1346637..1346729	+	93	WP_079877499.1	DUF3265 domain-containing protein	-
EHC70_RS06780	1347367..1347798	-	432	WP_043038654.1	hypothetical protein	-
EHC70_RS06785	1348576..1348923	+	348	WP_031410908.1	hypothetical protein	-
EHC70_RS06790	1349076..1349609	+	534	WP_140104155.1	hypothetical protein	-
EHC70_RS06795	1349745..1350512	+	768	WP_159404085.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1313607..1376491	62884
	-	inside	Integron	-	-	1314131..1374032	59901

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11543.16 Da
• Isoelectric Point: 8.0336

>T115680 WP_159404083.1 NZ_CP034285:c1345610-1345311 [Vibrio parahaemolyticus]
MQKNKYKLSNLAQSHLRKVKDYTVENFSELQWRNYKDTLLSGFQMLADNPDLGRSCDEIYPNGFFFPIGKHTAYFIKEDD
FILVVGVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T115680 NZ_CP034285:c1345610-1345311 [Vibrio parahaemolyticus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAGACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACTCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGACTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTTTTTCCCGATTGGAAAACACACAGCTTATTTCATCAAAGAAGATGAC
TTTATCTTAGTCGTTGGTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9047.26 Da
• Isoelectric Point: 5.6926

>AT115680 WP_005442033.1 NZ_CP034285:c1345860-1345618 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT115680 NZ_CP034285:c1345860-1345618 [Vibrio parahaemolyticus]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTGAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGATGGTGAAAGCTTTCTGAACTCGCTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A347UQT2