Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4753335..4754038 Replicon chromosome
Accession NZ_CP034281
Organism Klebsiella pneumoniae strain I72

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag EI552_RS23725 Protein ID WP_071994632.1
Coordinates 4753335..4753676 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag EI552_RS23730 Protein ID WP_032434296.1
Coordinates 4753697..4754038 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EI552_RS23715 4749650..4750519 + 870 WP_023317468.1 HNH endonuclease -
EI552_RS23720 4751110..4753143 + 2034 WP_050598589.1 hypothetical protein -
EI552_RS23725 4753335..4753676 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
EI552_RS23730 4753697..4754038 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EI552_RS23735 4754049..4754591 - 543 WP_032434298.1 DNA repair protein RadC -
EI552_RS23740 4754604..4755044 - 441 WP_032434300.1 antirestriction protein -
EI552_RS23745 4755075..4755896 - 822 WP_032434301.1 DUF945 domain-containing protein -
EI552_RS23750 4756016..4756489 - 474 WP_032434303.1 hypothetical protein -
EI552_RS23755 4756561..4757013 - 453 WP_032410767.1 hypothetical protein -
EI552_RS23760 4757049..4757765 - 717 WP_032434305.1 WYL domain-containing protein -
EI552_RS23765 4758009..4758883 - 875 Protein_4582 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T115675 WP_071994632.1 NZ_CP034281:c4753676-4753335 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

>T115675 NZ_CP034281:c4753676-4753335 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT115675 WP_032434296.1 NZ_CP034281:c4754038-4753697 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT115675 NZ_CP034281:c4754038-4753697 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References