Detailed information of TA system TA115659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 5230990..5231516
• Replicon: chromosome
• Accession: NZ_CP034279
• Organism: Streptomyces ficellus strain NRRL 8067

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EIZ62_RS23450
• Protein ID: WP_156694665.1
• Coordinates: 5230990..5231247 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EIZ62_RS23455
• Protein ID: WP_156694666.1
• Coordinates: 5231244..5231516 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIZ62_RS23430	5227865..5228389	-	525	WP_208828016.1	ATP-binding protein	-
EIZ62_RS23435	5228617..5229447	+	831	WP_156694662.1	helix-turn-helix domain-containing protein	-
EIZ62_RS23440	5229444..5229647	+	204	WP_156694663.1	DUF397 domain-containing protein	-
EIZ62_RS23445	5229777..5230544	+	768	Protein_4619	hypothetical protein	-
EIZ62_RS23450	5230990..5231247	-	258	WP_156694665.1	Txe/YoeB family addiction module toxin	Toxin
EIZ62_RS23455	5231244..5231516	-	273	WP_156694666.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EIZ62_RS23460	5231851..5235738	+	3888	WP_156694667.1	phage resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10146.62 Da
• Isoelectric Point: 9.8613

>T115659 WP_156694665.1 NZ_CP034279:c5231247-5230990 [Streptomyces ficellus]
VRSVHFDPAAWEDFLFWLGSDRAMARRITRLIAEIQRTPFTGIGKPEPLKGDLSGYWSRRIDDEHRLVYRVDEKEVKILK
ARYHY

Nucleotide

• Length: 258 bp

>T115659 NZ_CP034279:c5231247-5230990 [Streptomyces ficellus]
GTGAGGAGTGTCCACTTCGACCCGGCCGCATGGGAGGACTTCCTGTTCTGGCTCGGCTCGGACCGTGCCATGGCCCGCAG
GATCACCCGGCTGATCGCCGAGATCCAGCGCACGCCTTTCACCGGCATCGGCAAGCCTGAGCCCCTGAAAGGCGACCTGT
CCGGTTACTGGTCACGGCGGATCGACGACGAGCACCGGCTCGTCTACCGGGTGGACGAGAAGGAAGTCAAGATCCTAAAG
GCCCGCTACCACTACTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9844.01 Da
• Isoelectric Point: 4.4609

>AT115659 WP_156694666.1 NZ_CP034279:c5231516-5231244 [Streptomyces ficellus]
MTISASEARKDLFPLIKRVNDDHTPVRISSKSGDAVLMSADDYDSWQETVYLLRSPANARSLMEAVARDRASEAVVTKTM
AELDDLAGDG

Nucleotide

• Length: 273 bp

>AT115659 NZ_CP034279:c5231516-5231244 [Streptomyces ficellus]
ATGACGATAAGTGCCAGCGAGGCCCGTAAGGACCTCTTTCCGCTCATCAAGCGCGTCAACGACGACCACACGCCCGTGCG
CATCAGCTCCAAGAGCGGCGACGCGGTGCTGATGTCCGCTGACGACTACGACTCCTGGCAGGAGACCGTCTACCTGCTGC
GCTCCCCCGCCAACGCGCGAAGCCTCATGGAAGCCGTCGCACGGGACAGGGCCAGCGAGGCCGTGGTCACCAAGACGATG
GCAGAGCTGGACGACCTGGCGGGTGACGGGTGA