Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4936883..4938471 Replicon chromosome
Accession NZ_CP034276
Organism Pectobacterium versatile strain 14A

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EIP93_RS22315 Protein ID WP_125233290.1
Coordinates 4936883..4938202 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EIP93_RS22320 Protein ID WP_103943261.1
Coordinates 4938202..4938471 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIP93_RS22290 4932856..4932996 + 141 WP_005976668.1 50S ribosomal protein L34 -
EIP93_RS22295 4933015..4933374 + 360 WP_010302382.1 ribonuclease P protein component -
EIP93_RS22300 4933338..4933595 + 258 WP_010302384.1 membrane protein insertion efficiency factor YidD -
EIP93_RS22305 4933598..4935232 + 1635 WP_039485128.1 membrane protein insertase YidC -
EIP93_RS22310 4935362..4936726 + 1365 WP_103862404.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
EIP93_RS22315 4936883..4938202 - 1320 WP_125233290.1 type II toxin-antitoxin system HipA family toxin Toxin
EIP93_RS22320 4938202..4938471 - 270 WP_103943261.1 helix-turn-helix domain-containing protein Antitoxin
EIP93_RS22325 4938629..4939195 + 567 WP_103862406.1 hypothetical protein -
EIP93_RS22330 4939346..4940251 + 906 WP_125233291.1 HNH endonuclease -
EIP93_RS22335 4940315..4941166 - 852 WP_040032822.1 SDR family oxidoreductase -
EIP93_RS22340 4941281..4941691 + 411 WP_103862408.1 helix-turn-helix transcriptional regulator -
EIP93_RS22345 4941741..4942295 - 555 WP_103943265.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49277.44 Da        Isoelectric Point: 6.5030

>T115658 WP_125233290.1 NZ_CP034276:c4938202-4936883 [Pectobacterium versatile]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLDKVGKDSIGALQIVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPFSTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILAEFAQTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T115658 NZ_CP034276:c4938202-4936883 [Pectobacterium versatile]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTAGGGATTCTGACCAAAACGGGCAGTGGGGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGATTGCCGGGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGCCCTATCAAG
GCGATGAAGTTTATAACTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGACGGATTGTCGCCAGGCATCAC
GCGGATTCCACCCAACCGTTTGATCTGCTGGATAAAGTGGGGAAAGACAGTATCGGGGCGTTGCAAATAGTGCCGCAGGG
TACACCTGTGCACGATATAAAAAAGATCGAATACAAAACCTTATCCGAGCAGCAGCTTGAAAACATACTGACCGGATATC
TGTCCGATGCCCCGCTGGGTATGATTGATACTGAAGACGATTTTCGTATTTCTATCGCAGGCGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGATCACTGGTGCCTGCCCTTCAGTACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGCCTGCTCATTGCCAAGGCAT
TTGGGCTGCCAGTGCCGCACTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGCTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGGTCGGTTGATCCAGAAAGAGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCCTGTTTATT
GAATCTGAGGGGCGATATCGACTCACACCTTTCTATGACATTCTCTCTATGTATCCGGCGATGGGCGGACGGGGAATTGA
CCGCAGAGAGGCCAAACTGGCGATGGGATTAACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTTCCCCGGC
ATTTTTTCCAGACGGCGAAGGCCGTTGGGTTTGCCAGAGAATCAATGGAAAACATTCTGGCGGAGTTTGCACAAACCGTT
GAGACCGTTATGACGACTGTTGGAAGCCAACTGCCTGTGGATTTTCCTACTCATATCAGTGAGGCAATTCTGGCCGGATT
GCAGGCCAGATCGAGACGGCTCATGAGCGGATGGGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10062.40 Da        Isoelectric Point: 9.7281

>AT115658 WP_103943261.1 NZ_CP034276:c4938471-4938202 [Pectobacterium versatile]
MMKITNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEAS
VASSWKEEW

Download         Length: 270 bp

>AT115658 NZ_CP034276:c4938471-4938202 [Pectobacterium versatile]
ATGATGAAGATCACCAACAGCAAGCAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAA
AGTGGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGTTTCGAGCAACATCCTGATTCCACTAAGCTGGAAACCT
TCTTTAAAATCCTGTCGGCATTGAATTTAGAACTTACTGTTACGCCCAGGAATGTGGACACCACCAATAACGAAGCCTCT
GTTGCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References