Detailed information of TA system TA115655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4754047..4754681
• Replicon: chromosome
• Accession: NZ_CP034276
• Organism: Pectobacterium versatile strain 14A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EIP93_RS21525
• Protein ID: WP_103862315.1
• Coordinates: 4754406..4754681 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A221T3Z5
• Locus tag: EIP93_RS21520
• Protein ID: WP_010308714.1
• Coordinates: 4754047..4754409 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIP93_RS21515	4750043..4753786	-	3744	WP_125233250.1	DUF4132 domain-containing protein	-
EIP93_RS21520	4754047..4754409	-	363	WP_010308714.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EIP93_RS21525	4754406..4754681	-	276	WP_103862315.1	type II toxin-antitoxin system HicA family toxin	Toxin
EIP93_RS21530	4754911..4755435	-	525	WP_103943770.1	cell-envelope stress modulator CpxP	-
EIP93_RS21535	4755589..4756287	+	699	WP_010308725.1	envelope stress response regulator transcription factor CpxR	-
EIP93_RS21540	4756284..4757654	+	1371	WP_103862317.1	envelope stress sensor histidine kinase CpxA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10006.60 Da
• Isoelectric Point: 11.1875

>T115655 WP_103862315.1 NZ_CP034276:c4754681-4754406 [Pectobacterium versatile]
MQGKIASLRKKQRETLSHIFKTPVLSGVKWSSIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T115655 NZ_CP034276:c4754681-4754406 [Pectobacterium versatile]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACACTGAGCCACATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAGTATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGGTCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGGTTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGTGCCCTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13495.29 Da
• Isoelectric Point: 4.6225

>AT115655 WP_010308714.1 NZ_CP034276:c4754409-4754047 [Pectobacterium versatile]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERHISVNTFIVETLSEHLKQA

Nucleotide

• Length: 363 bp

>AT115655 NZ_CP034276:c4754409-4754047 [Pectobacterium versatile]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCTGCCATTATCAGTTACGTACCGGAAATTGG
TATGTTTCGTGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTACCCTGAATCATTCGGGGAACGACTGACCATTGCGGCCGCTGAACGTCACATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A221T3Z5