Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4705387..4706004 Replicon chromosome
Accession NZ_CP034276
Organism Pectobacterium versatile strain 14A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EIP93_RS21320 Protein ID WP_103862292.1
Coordinates 4705387..4705566 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EIP93_RS21325 Protein ID WP_103862293.1
Coordinates 4705594..4706004 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIP93_RS21295 4700622..4701782 - 1161 WP_010299271.1 cystathionine gamma-synthase -
EIP93_RS21300 4701970..4702287 + 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
EIP93_RS21305 4702511..4703308 + 798 WP_125233239.1 ABC transporter ATP-binding protein -
EIP93_RS21310 4703318..4704280 + 963 WP_103862290.1 ABC transporter substrate-binding protein -
EIP93_RS21315 4704277..4705287 + 1011 WP_107333586.1 iron ABC transporter permease -
EIP93_RS21320 4705387..4705566 + 180 WP_103862292.1 type II toxin-antitoxin system HicA family toxin Toxin
EIP93_RS21325 4705594..4706004 + 411 WP_103862293.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EIP93_RS21330 4706087..4706302 - 216 WP_010281510.1 50S ribosomal protein L31 -
EIP93_RS21335 4706574..4708772 + 2199 WP_103943585.1 primosomal protein N' -
EIP93_RS21340 4709067..4710110 + 1044 WP_103862295.1 DNA-binding transcriptional regulator CytR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6546.67 Da        Isoelectric Point: 10.7838

>T115654 WP_103862292.1 NZ_CP034276:4705387-4705566 [Pectobacterium versatile]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGV

Download         Length: 180 bp

>T115654 NZ_CP034276:4705387-4705566 [Pectobacterium versatile]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGGTTAGTCACAATCCCCCACCCGAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAGTATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14461.35 Da        Isoelectric Point: 4.4227

>AT115654 WP_103862293.1 NZ_CP034276:4705594-4706004 [Pectobacterium versatile]
MFYPIAIEAGDETHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIGLLVEMGQDIPTVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT115654 NZ_CP034276:4705594-4706004 [Pectobacterium versatile]
ATGTTTTATCCTATTGCAATTGAAGCAGGCGACGAGACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGTTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGGACTGTTGGTCGAAA
TGGGCCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTAGCAAAAAACGCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATTGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAACGTCACGCTGCCTAAGTCGCTGATTGACCGCAT
TGATCGTTGCGTGGCGAGTAACCCAGAATTTAAAAGTCGTTCGGGTTTTCTCGCACAGGCGGCATTAGAACGAATCTCGT
CTTCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References