Detailed information of TA system TA115648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1412121..1412757
• Replicon: chromosome
• Accession: NZ_CP034276
• Organism: Pectobacterium versatile strain 14A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7V8QAU7
• Locus tag: EIP93_RS06350
• Protein ID: WP_039485998.1
• Coordinates: 1412121..1412303 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EIP93_RS06355
• Protein ID: WP_107332493.1
• Coordinates: 1412326..1412757 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIP93_RS06325	1407513..1407716	+	204	WP_040031402.1	YbdD/YjiX family protein	-
EIP93_RS06330	1407733..1408695	+	963	WP_107332491.1	GTPase	-
EIP93_RS06335	1408961..1410343	+	1383	WP_116226779.1	right-handed parallel beta-helix repeat-containing protein	-
EIP93_RS06340	1410577..1411056	-	480	WP_103860136.1	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	-
EIP93_RS06345	1411127..1411945	-	819	WP_107332492.1	TraB/GumN family protein	-
EIP93_RS06350	1412121..1412303	+	183	WP_039485998.1	type II toxin-antitoxin system HicA family toxin	Toxin
EIP93_RS06355	1412326..1412757	+	432	WP_107332493.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EIP93_RS06360	1412852..1415575	-	2724	WP_125232443.1	copper-exporting P-type ATPase CopA	-
EIP93_RS06365	1415692..1416099	+	408	WP_125232444.1	Cu(I)-responsive transcriptional regulator	-
EIP93_RS06370	1416135..1416590	-	456	WP_125232445.1	NfeD family protein	-
EIP93_RS06375	1416590..1417504	-	915	WP_010301277.1	SPFH/Band 7/PHB domain protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-138)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6539.74 Da
• Isoelectric Point: 10.5014

>T115648 WP_039485998.1 NZ_CP034276:1412121-1412303 [Pectobacterium versatile]
MKSTDLIKELAAAGCECKRHNGGSHQIWWSPITGKTFPVPHPKKDLPLGTVKSIKKMAGI

Nucleotide

• Length: 183 bp

>T115648 NZ_CP034276:1412121-1412303 [Pectobacterium versatile]
ATGAAATCAACTGACCTGATAAAGGAGCTGGCAGCGGCAGGTTGTGAGTGCAAACGGCATAACGGCGGGAGTCACCAAAT
ATGGTGGTCACCCATTACTGGAAAAACATTTCCAGTGCCGCATCCAAAAAAGGATTTACCACTTGGAACTGTCAAATCCA
TCAAAAAAATGGCGGGGATCTGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 16036.95 Da
• Isoelectric Point: 4.3145

>AT115648 WP_107332493.1 NZ_CP034276:1412326-1412757 [Pectobacterium versatile]
MFFSVGVETPKDDATAYGLIVPALCTDDYGCFSAADSQQEIARMAREAILTLIDEAVSRGNLDIKRLNDAGHLIYAAIPD
FADYDSWFVLDVDLSAFEGKPQRLNISLPDTLIQRIDNRVREQPGTYRDRSHFLAEAARHELE

Nucleotide

• Length: 432 bp

>AT115648 NZ_CP034276:1412326-1412757 [Pectobacterium versatile]
ATGTTTTTTTCAGTCGGTGTTGAAACGCCAAAAGATGATGCTACGGCATATGGGCTGATCGTTCCGGCGTTGTGTACTGA
TGATTATGGCTGCTTCTCTGCAGCTGACAGCCAACAAGAGATTGCACGCATGGCGCGGGAAGCGATTTTAACCCTTATTG
ATGAAGCGGTGAGCCGCGGAAATCTGGATATTAAACGACTTAATGATGCTGGACATCTCATCTATGCGGCAATACCAGAT
TTTGCGGACTACGATAGTTGGTTCGTGCTGGATGTGGATTTATCGGCTTTTGAGGGAAAACCGCAGCGATTGAACATTTC
ACTTCCCGATACGTTGATACAGCGTATTGATAATCGCGTGCGAGAGCAGCCGGGTACTTATCGCGATCGCAGCCATTTTT
TGGCAGAAGCCGCACGCCATGAACTGGAGTGA

Structures

Toxin

• AlphaFold DB: A0A7V8QAU7