Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4069656..4070275 Replicon chromosome
Accession NZ_CP034249
Organism Klebsiella pneumoniae strain KP18-29

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag EIL78_RS20535 Protein ID WP_002892050.1
Coordinates 4070057..4070275 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag EIL78_RS20530 Protein ID WP_002892066.1
Coordinates 4069656..4070030 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIL78_RS20520 4064808..4066001 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EIL78_RS20525 4066024..4069170 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
EIL78_RS20530 4069656..4070030 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
EIL78_RS20535 4070057..4070275 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
EIL78_RS20540 4070434..4071000 + 567 WP_002892030.1 maltose O-acetyltransferase -
EIL78_RS27830 4070972..4071112 - 141 WP_004147370.1 hypothetical protein -
EIL78_RS20545 4071133..4071603 + 471 WP_002892026.1 YlaC family protein -
EIL78_RS20550 4071578..4073029 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
EIL78_RS20555 4073130..4073828 + 699 Protein_3971 GNAT family N-acetyltransferase -
EIL78_RS20560 4073825..4073965 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
EIL78_RS20565 4073965..4074228 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T115614 WP_002892050.1 NZ_CP034249:4070057-4070275 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T115614 NZ_CP034249:4070057-4070275 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT115614 WP_002892066.1 NZ_CP034249:4069656-4070030 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT115614 NZ_CP034249:4069656-4070030 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References