Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4069656..4070275 | Replicon | chromosome |
Accession | NZ_CP034249 | ||
Organism | Klebsiella pneumoniae strain KP18-29 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | EIL78_RS20535 | Protein ID | WP_002892050.1 |
Coordinates | 4070057..4070275 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | EIL78_RS20530 | Protein ID | WP_002892066.1 |
Coordinates | 4069656..4070030 (+) | Length | 125 a.a. |
Genomic Context
Location: 4064808..4066001 (1194 bp)
Type: Others
Protein ID: WP_002892072.1
Type: Others
Protein ID: WP_002892072.1
Location: 4066024..4069170 (3147 bp)
Type: Others
Protein ID: WP_002892069.1
Type: Others
Protein ID: WP_002892069.1
Location: 4069656..4070030 (375 bp)
Type: Antitoxin
Protein ID: WP_002892066.1
Type: Antitoxin
Protein ID: WP_002892066.1
Location: 4070057..4070275 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Type: Toxin
Protein ID: WP_002892050.1
Location: 4070434..4071000 (567 bp)
Type: Others
Protein ID: WP_002892030.1
Type: Others
Protein ID: WP_002892030.1
Location: 4071133..4071603 (471 bp)
Type: Others
Protein ID: WP_002892026.1
Type: Others
Protein ID: WP_002892026.1
Location: 4073130..4073828 (699 bp)
Type: Others
Protein ID: Protein_3971
Type: Others
Protein ID: Protein_3971
Location: 4070972..4071112 (141 bp)
Type: Others
Protein ID: WP_004147370.1
Type: Others
Protein ID: WP_004147370.1
Location: 4071578..4073029 (1452 bp)
Type: Others
Protein ID: WP_002892023.1
Type: Others
Protein ID: WP_002892023.1
Location: 4073825..4073965 (141 bp)
Type: Others
Protein ID: WP_002892018.1
Type: Others
Protein ID: WP_002892018.1
Location: 4073965..4074228 (264 bp)
Type: Others
Protein ID: WP_002892011.1
Type: Others
Protein ID: WP_002892011.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EIL78_RS20520 | 4064808..4066001 | + | 1194 | WP_002892072.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
EIL78_RS20525 | 4066024..4069170 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
EIL78_RS20530 | 4069656..4070030 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
EIL78_RS20535 | 4070057..4070275 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
EIL78_RS20540 | 4070434..4071000 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
EIL78_RS27830 | 4070972..4071112 | - | 141 | WP_004147370.1 | hypothetical protein | - |
EIL78_RS20545 | 4071133..4071603 | + | 471 | WP_002892026.1 | YlaC family protein | - |
EIL78_RS20550 | 4071578..4073029 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
EIL78_RS20555 | 4073130..4073828 | + | 699 | Protein_3971 | GNAT family N-acetyltransferase | - |
EIL78_RS20560 | 4073825..4073965 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
EIL78_RS20565 | 4073965..4074228 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T115614 WP_002892050.1 NZ_CP034249:4070057-4070275 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T115614 NZ_CP034249:4070057-4070275 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT115614 WP_002892066.1 NZ_CP034249:4069656-4070030 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT115614 NZ_CP034249:4069656-4070030 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |