Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4069656..4070275 Replicon chromosome
Accession NZ_CP034249
Organism Klebsiella pneumoniae strain KP18-29

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag EIL78_RS20535 Protein ID WP_002892050.1
Coordinates 4070057..4070275 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag EIL78_RS20530 Protein ID WP_002892066.1
Coordinates 4069656..4070030 (+) Length 125 a.a.

Genomic Context


EIL78_RS20520EIL78_RS20525EIL78_RS20530EIL78_RS20535EIL78_RS20540EIL78_RS20545EIL78_RS20555EIL78_RS27830EIL78_RS20550EIL78_RS20560EIL78_RS20565
Location: 4064808..4066001 (1194 bp)
Type: Others
Protein ID: WP_002892072.1
Location: 4066024..4069170 (3147 bp)
Type: Others
Protein ID: WP_002892069.1
Location: 4069656..4070030 (375 bp)
Type: Antitoxin
Protein ID: WP_002892066.1
Location: 4070057..4070275 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Location: 4070434..4071000 (567 bp)
Type: Others
Protein ID: WP_002892030.1
Location: 4071133..4071603 (471 bp)
Type: Others
Protein ID: WP_002892026.1
Location: 4073130..4073828 (699 bp)
Type: Others
Protein ID: Protein_3971
Location: 4070972..4071112 (141 bp)
Type: Others
Protein ID: WP_004147370.1
Location: 4071578..4073029 (1452 bp)
Type: Others
Protein ID: WP_002892023.1
Location: 4073825..4073965 (141 bp)
Type: Others
Protein ID: WP_002892018.1
Location: 4073965..4074228 (264 bp)
Type: Others
Protein ID: WP_002892011.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EIL78_RS205204064808..4066001+1194WP_002892072.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
EIL78_RS205254066024..4069170+3147WP_002892069.1multidrug efflux RND transporter permease subunit AcrB-
EIL78_RS205304069656..4070030+375WP_002892066.1Hha toxicity modulator TomBAntitoxin
EIL78_RS205354070057..4070275+219WP_002892050.1hemolysin expression modulator HhaToxin
EIL78_RS205404070434..4071000+567WP_002892030.1maltose O-acetyltransferase-
EIL78_RS278304070972..4071112-141WP_004147370.1hypothetical protein-
EIL78_RS205454071133..4071603+471WP_002892026.1YlaC family protein-
EIL78_RS205504071578..4073029-1452WP_002892023.1PLP-dependent aminotransferase family protein-
EIL78_RS205554073130..4073828+699Protein_3971GNAT family N-acetyltransferase-
EIL78_RS205604073825..4073965-141WP_002892018.1type B 50S ribosomal protein L36-
EIL78_RS205654073965..4074228-264WP_002892011.1type B 50S ribosomal protein L31-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T115614 WP_002892050.1 NZ_CP034249:4070057-4070275 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T115614 NZ_CP034249:4070057-4070275 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT115614 WP_002892066.1 NZ_CP034249:4069656-4070030 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT115614 NZ_CP034249:4069656-4070030 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A2P8K6F2


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GJ93

References