Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2212546..2213181 Replicon chromosome
Accession NZ_CP034248
Organism Paenibacillus lentus strain DSM 25539

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EIM92_RS09920 Protein ID WP_125082509.1
Coordinates 2212831..2213181 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag EIM92_RS09915 Protein ID WP_019638235.1
Coordinates 2212546..2212827 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIM92_RS09900 2208265..2209515 + 1251 WP_125082507.1 MFS transporter -
EIM92_RS09905 2209761..2210870 + 1110 WP_125082508.1 outer membrane lipoprotein carrier protein LolA -
EIM92_RS09910 2211104..2212288 + 1185 WP_125085106.1 alanine racemase -
EIM92_RS09915 2212546..2212827 + 282 WP_019638235.1 ribbon-helix-helix protein, CopG family Antitoxin
EIM92_RS09920 2212831..2213181 + 351 WP_125082509.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EIM92_RS09925 2213362..2213727 + 366 WP_125082510.1 DUF4190 domain-containing protein -
EIM92_RS09930 2213970..2216189 + 2220 WP_125082511.1 RNA-binding transcriptional accessory protein -
EIM92_RS09935 2216454..2216777 + 324 WP_125082512.1 hypothetical protein -
EIM92_RS09940 2216805..2217182 + 378 WP_125082513.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12820.83 Da        Isoelectric Point: 5.6195

>T115600 WP_125082509.1 NZ_CP034248:2212831-2213181 [Paenibacillus lentus]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIEAATHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDETMKKVNDSLLISLGLIDF

Download         Length: 351 bp

>T115600 NZ_CP034248:2212831-2213181 [Paenibacillus lentus]
TTGATTGTAAAGCGCGGCGACGTATTTTTTGCAGACCTTTCCCCTGTTGTCGGCTCTGAGCAGGGAGGGGTAAGACCTGT
GCTTATCATCCAGAACGATATTGGCAATCGATTCAGCCCGACGGTAATCGTTGCTGCTATTACTGCCCAAATTCAAAAAG
CGAAGCTGCCAACTCATGTAGAGATTGAAGCAGCAACGCATGGTTTTGACCGGGATTCTGTCATTTTGCTTGAACAGATA
CGAACGATTGATAAGCAGAGATTGACGGATAAAATTACGCATCTGGATGATGAGACGATGAAGAAGGTTAACGATTCGCT
GCTTATTAGTCTCGGATTAATTGATTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10762.42 Da        Isoelectric Point: 6.4710

>AT115600 WP_019638235.1 NZ_CP034248:2212546-2212827 [Paenibacillus lentus]
MANMQNTKRIMISLPDHLLQEVDGIVAMENSNRSELIRQAMKLYLNERKKRFIRESMQRGYMEMAKINLTMASEAFHAEE
DADSTLDRLVSGV

Download         Length: 282 bp

>AT115600 NZ_CP034248:2212546-2212827 [Paenibacillus lentus]
ATGGCCAATATGCAGAACACCAAAAGAATTATGATCAGCTTACCGGATCATCTATTGCAGGAAGTGGATGGAATCGTTGC
TATGGAGAACTCCAATCGTAGTGAGCTTATTAGGCAAGCCATGAAGCTGTATTTAAATGAACGGAAGAAGCGTTTCATCC
GGGAATCTATGCAGCGGGGCTACATGGAAATGGCCAAGATTAACTTAACCATGGCCTCGGAAGCTTTCCACGCGGAGGAA
GATGCAGACAGCACTCTGGACCGCCTAGTTAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References