Detailed information of TA system TA115600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-pemI/MazF(toxin)
• Location: 2212546..2213181
• Replicon: chromosome
• Accession: NZ_CP034248
• Organism: Paenibacillus lentus strain DSM 25539

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: EIM92_RS09920
• Protein ID: WP_125082509.1
• Coordinates: 2212831..2213181 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: EIM92_RS09915
• Protein ID: WP_019638235.1
• Coordinates: 2212546..2212827 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIM92_RS09900	2208265..2209515	+	1251	WP_125082507.1	MFS transporter	-
EIM92_RS09905	2209761..2210870	+	1110	WP_125082508.1	outer membrane lipoprotein carrier protein LolA	-
EIM92_RS09910	2211104..2212288	+	1185	WP_125085106.1	alanine racemase	-
EIM92_RS09915	2212546..2212827	+	282	WP_019638235.1	ribbon-helix-helix protein, CopG family	Antitoxin
EIM92_RS09920	2212831..2213181	+	351	WP_125082509.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
EIM92_RS09925	2213362..2213727	+	366	WP_125082510.1	DUF4190 domain-containing protein	-
EIM92_RS09930	2213970..2216189	+	2220	WP_125082511.1	RNA-binding transcriptional accessory protein	-
EIM92_RS09935	2216454..2216777	+	324	WP_125082512.1	hypothetical protein	-
EIM92_RS09940	2216805..2217182	+	378	WP_125082513.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12820.83 Da
• Isoelectric Point: 5.6195

>T115600 WP_125082509.1 NZ_CP034248:2212831-2213181 [Paenibacillus lentus]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIEAATHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDETMKKVNDSLLISLGLIDF

Nucleotide

• Length: 351 bp

>T115600 NZ_CP034248:2212831-2213181 [Paenibacillus lentus]
TTGATTGTAAAGCGCGGCGACGTATTTTTTGCAGACCTTTCCCCTGTTGTCGGCTCTGAGCAGGGAGGGGTAAGACCTGT
GCTTATCATCCAGAACGATATTGGCAATCGATTCAGCCCGACGGTAATCGTTGCTGCTATTACTGCCCAAATTCAAAAAG
CGAAGCTGCCAACTCATGTAGAGATTGAAGCAGCAACGCATGGTTTTGACCGGGATTCTGTCATTTTGCTTGAACAGATA
CGAACGATTGATAAGCAGAGATTGACGGATAAAATTACGCATCTGGATGATGAGACGATGAAGAAGGTTAACGATTCGCT
GCTTATTAGTCTCGGATTAATTGATTTTTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10762.42 Da
• Isoelectric Point: 6.4710

>AT115600 WP_019638235.1 NZ_CP034248:2212546-2212827 [Paenibacillus lentus]
MANMQNTKRIMISLPDHLLQEVDGIVAMENSNRSELIRQAMKLYLNERKKRFIRESMQRGYMEMAKINLTMASEAFHAEE
DADSTLDRLVSGV

Nucleotide

• Length: 282 bp

>AT115600 NZ_CP034248:2212546-2212827 [Paenibacillus lentus]
ATGGCCAATATGCAGAACACCAAAAGAATTATGATCAGCTTACCGGATCATCTATTGCAGGAAGTGGATGGAATCGTTGC
TATGGAGAACTCCAATCGTAGTGAGCTTATTAGGCAAGCCATGAAGCTGTATTTAAATGAACGGAAGAAGCGTTTCATCC
GGGAATCTATGCAGCGGGGCTACATGGAAATGGCCAAGATTAACTTAACCATGGCCTCGGAAGCTTTCCACGCGGAGGAA
GATGCAGACAGCACTCTGGACCGCCTAGTTAGCGGGGTGTGA