Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4040753..4042293 Replicon chromosome
Accession NZ_CP034246
Organism Shewanella algae strain VGH117

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EIY89_RS18020 Protein ID WP_190533407.1
Coordinates 4040753..4042054 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EIY89_RS18025 Protein ID WP_093982108.1
Coordinates 4042057..4042293 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIY89_RS17990 4035975..4036238 + 264 WP_144160672.1 hypothetical protein -
EIY89_RS17995 4036288..4036722 + 435 WP_020442396.1 HNH endonuclease -
EIY89_RS18000 4037061..4037408 + 348 WP_025011793.1 hypothetical protein -
EIY89_RS18005 4037835..4038998 + 1164 WP_109248697.1 RNA ligase RtcB family protein -
EIY89_RS18010 4038998..4039633 + 636 WP_190533400.1 peptide chain release factor H -
EIY89_RS18015 4039739..4040692 - 954 WP_190533402.1 sel1 repeat family protein -
EIY89_RS18020 4040753..4042054 - 1302 WP_190533407.1 HipA domain-containing protein Toxin
EIY89_RS18025 4042057..4042293 - 237 WP_093982108.1 helix-turn-helix domain-containing protein Antitoxin
EIY89_RS18030 4042503..4043087 - 585 WP_190533410.1 cold shock domain-containing protein -
EIY89_RS18035 4043264..4043446 - 183 WP_144226198.1 cold shock domain-containing protein -
EIY89_RS18040 4043946..4044146 - 201 WP_190533412.1 hypothetical protein -
EIY89_RS18045 4044216..4044602 + 387 WP_190533416.1 AAA family ATPase -
EIY89_RS18050 4044524..4046155 + 1632 WP_190533419.1 AAA family ATPase -
EIY89_RS18055 4046160..4046780 + 621 WP_117199987.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48596.32 Da        Isoelectric Point: 4.6937

>T115599 WP_190533407.1 NZ_CP034246:c4042054-4040753 [Shewanella algae]
MSGAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWQQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEEPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKAIAMNVANVEIRHFGQHKSLCVERFDRRYLPAEQRVQRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRDLVRNSLTRMATRISQEIDGVIAMLNGLD
NDEQAFVASYKAQLLARCERYLDIAPQINEMEL

Download         Length: 1302 bp

>T115599 NZ_CP034246:c4042054-4040753 [Shewanella algae]
ATGAGTGGAGCAGCAAACCTTGTCTTGGATATGCATCTTGGTGATCGAATCATAGGTGAGTTGTCATTCGACCCCGCCAC
CGAGAGTTTTGCCGTCAGTTACAGCCAAGATTGGCAGCAAAACGGCTTTCCCATATCACCCATGATCCCTTTGGATGGCA
CAGGAAGCAGCACACAGATCGCCATGTTTCTCGGCAACCTGTTGCCCGAAAACAGGGGTTTGGATTATCTCATCGAATCT
CTTGGTGTATCCAGGGGCAATACCTTTGCCCTTATCCGAGCCATTGGCCTGGATACTGCCGGTGCCGTTGCCTTTTCTCC
CAAGGGGACTGAACTGCCACAGACGGCATTTCGAGAAATCAGTGATGATGAAATCATTTTGCGCCTGGAAGAGCCTGAAC
TCTGGCCAATGGAGGTGTGGGATGGCAAGCCCAGGCTGTCGGTAGCCGGGGTACAGTCAAAACTGAATCTATTCTACAAC
GGCAAGCAATTTGGTTTCGGTGAAGGCGCCTTATCATCGACCCATATCCTGAAGTTCGAAAAGCAGCGGCATTTAGTCAT
CAACGAGTTTCTCACTATGCGTTTGGCGAAGGCGATAGCCATGAATGTCGCGAATGTTGAGATCCGCCATTTTGGCCAGC
ACAAATCATTGTGTGTCGAACGCTTTGATCGTCGTTATTTGCCCGCTGAACAGCGGGTGCAGAGAAGGCATATTATCGAT
AGCTGCCAAGCCCTTGGCTTTAGTGTGAATAAGAAATACGAACGAAATTTTGGTAATGGCCGTGATGTCAGAGATATTCG
CGAAGGTGTTAGCCTTCCCAGGCTGTTTGCTCTTGCGGAGCAATGCGCTAATCCGGCGGCGGCCAAACAGGATATGCTGC
AGTGGACGCTGTTTAATCTACTGAGTGGCAACGCCGATGCTCATGGTAAAAACTACTCCTTCTTCATGACACCGACAGGT
ATGGTGCCTACGCCTTGGTATGACTTGGTTTGCGTGGCCTTGTATGAGGAATTTGAGCAAGAGCTGGCGATGGCGATTGA
TGATGAATTCGACCCAGACAAGATCTACGCCTATCAATTGGCCGCGTTCAGCGAGGATATAGGGTTACCCAGAGACTTGG
TGCGCAACAGCCTAACCAGAATGGCGACCAGAATAAGCCAAGAAATAGACGGTGTTATCGCAATGCTCAATGGATTGGAT
AACGATGAGCAGGCGTTTGTGGCGAGCTACAAAGCACAGTTATTGGCAAGGTGTGAGCGCTATTTGGATATTGCCCCCCA
AATCAATGAGATGGAACTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8487.03 Da        Isoelectric Point: 9.6887

>AT115599 WP_093982108.1 NZ_CP034246:c4042293-4042057 [Shewanella algae]
MASPLTPHSLGALIKARRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIRLLAQPKPDVDSTGWY

Download         Length: 237 bp

>AT115599 NZ_CP034246:c4042293-4042057 [Shewanella algae]
ATGGCCTCCCCATTAACTCCACATTCATTGGGCGCTTTAATTAAGGCCCGTAGAAAAGAAGCGGCACTCACTCTGGATGT
GGCGGCAATGCTTTGTGGTGTCACCAAGAAAACCTTCATCCGGGTCGAGAAGGGTGAGGATGTCTACATCTCTACTGTCT
TCAAGATACTCGATGGTTTGGGGATCCGTCTGCTGGCGCAGCCCAAGCCTGATGTTGATTCGACCGGGTGGTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References