Detailed information of TA system TA115593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1605322..1606001
• Replicon: chromosome
• Accession: NZ_CP034242
• Organism: Acinetobacter baumannii isolate 09A16CRGN0014

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: EI069_RS07770
• Protein ID: WP_000838146.1
• Coordinates: 1605322..1605504 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: EI069_RS07775
• Protein ID: WP_000966688.1
• Coordinates: 1605597..1606001 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EI069_RS07725	1600395..1600799	+	405	WP_000247948.1	hypothetical protein	-
EI069_RS07730	1600771..1601139	+	369	WP_002055488.1	hypothetical protein	-
EI069_RS07735	1601141..1601539	+	399	WP_001251850.1	hypothetical protein	-
EI069_RS07740	1601541..1601759	+	219	WP_001277687.1	hypothetical protein	-
EI069_RS07745	1601853..1602206	+	354	WP_000064599.1	hypothetical protein	-
EI069_RS07750	1602206..1603441	+	1236	WP_000002422.1	hypothetical protein	-
EI069_RS07755	1603494..1604411	+	918	WP_000094250.1	hypothetical protein	-
EI069_RS07760	1604481..1604996	+	516	WP_001185608.1	hypothetical protein	-
EI069_RS07770	1605322..1605504	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
EI069_RS07775	1605597..1606001	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EI069_RS07780	1606100..1606276	+	177	WP_014466185.1	hypothetical protein	-
EI069_RS07785	1606285..1606608	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
EI069_RS07790	1606640..1607434	+	795	WP_000720608.1	hypothetical protein	-
EI069_RS07795	1607483..1607722	-	240	WP_000763623.1	Arc family DNA-binding protein	-
EI069_RS07800	1607845..1608000	+	156	WP_001103649.1	Arc family DNA-binding protein	-
EI069_RS07805	1607997..1608989	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1576212..1629287	53075

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T115593 WP_000838146.1 NZ_CP034242:1605322-1605504 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T115593 NZ_CP034242:1605322-1605504 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT115593 WP_000966688.1 NZ_CP034242:1605597-1606001 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT115593 NZ_CP034242:1605597-1606001 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6