Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 610713..611221 Replicon chromosome
Accession NZ_CP034241
Organism Aliivibrio salmonicida strain VS224

Toxin (Protein)


Gene name relB Uniprot ID B6ERH6
Locus tag EIJ81_RS20315 Protein ID WP_012551878.1
Coordinates 610961..611221 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B6ERH5
Locus tag EIJ81_RS20310 Protein ID WP_012551877.1
Coordinates 610713..610964 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIJ81_RS20285 606204..607796 - 1593 WP_012551872.1 RNA-directed DNA polymerase -
EIJ81_RS20295 608365..608559 - 195 WP_012551874.1 hypothetical protein -
EIJ81_RS23215 608725..608898 + 174 WP_012551875.1 hypothetical protein -
EIJ81_RS20300 609053..609937 + 885 WP_012551876.1 GIY-YIG nuclease family protein -
EIJ81_RS20310 610713..610964 + 252 WP_012551877.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EIJ81_RS20315 610961..611221 + 261 WP_012551878.1 Txe/YoeB family addiction module toxin Toxin
EIJ81_RS20325 611998..613143 + 1146 WP_012551880.1 IS91-like element ISVsa10 family transposase -
EIJ81_RS20330 613526..613783 + 258 WP_012551881.1 DUF4160 domain-containing protein -
EIJ81_RS20335 613791..614315 + 525 WP_012551882.1 DUF2442 domain-containing protein -
EIJ81_RS20345 615008..615412 + 405 WP_012551883.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 611998..616723 4725
- inside Integron - - 593550..615412 21862


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10249.68 Da        Isoelectric Point: 8.8610

>T115590 WP_012551878.1 NZ_CP034241:610961-611221 [Aliivibrio salmonicida]
MSRMLAWTDDAWDDYLYWQGQDKKTLKRINKLITDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVNDAHLTII
SCRYHY

Download         Length: 261 bp

>T115590 NZ_CP034241:610961-611221 [Aliivibrio salmonicida]
ATGAGTCGAATGTTAGCTTGGACTGACGATGCTTGGGATGATTACTTGTATTGGCAAGGTCAGGATAAGAAAACGCTGAA
ACGCATCAATAAATTAATTACTGATGTGAAGCGTTCTCCCTTCGAAGGTATTGGTAAACCTGAGCCATTGAAAGAAAATT
TGGCAGGTTTTTGGTCACGTAGAATTGATGACACCAACCGATTAGTTTATGCAGTTAATGATGCACATTTGACAATAATT
TCCTGTCGCTATCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9189.31 Da        Isoelectric Point: 4.6683

>AT115590 WP_012551877.1 NZ_CP034241:610713-610964 [Aliivibrio salmonicida]
MRIVSFTEARNGLKSVLDGVVNDADCTVITRRDSEDAVVMSMDYYNSLMETIYLSRSPANAAHLNKSIAQYNAGQTTERG
LLE

Download         Length: 252 bp

>AT115590 NZ_CP034241:610713-610964 [Aliivibrio salmonicida]
ATGCGTATAGTTTCTTTTACTGAAGCTCGAAATGGTCTTAAATCTGTTCTTGATGGCGTAGTTAATGATGCGGACTGCAC
AGTTATCACTCGTCGAGATTCTGAAGATGCAGTTGTAATGTCTATGGATTATTATAATAGCTTAATGGAAACGATTTATT
TATCTCGTTCTCCAGCTAATGCTGCTCATCTAAACAAATCAATTGCTCAATACAATGCTGGTCAAACTACGGAAAGAGGC
TTGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6ERH6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9PEW0

References