Detailed information of TA system TA115589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 605437..605977
• Replicon: chromosome
• Accession: NZ_CP034241
• Organism: Aliivibrio salmonicida strain VS224

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B6ERG8
• Locus tag: EIJ81_RS20275
• Protein ID: WP_012551870.1
• Coordinates: 605437..605706 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B6ERG9
• Locus tag: EIJ81_RS20280
• Protein ID: WP_012551871.1
• Coordinates: 605699..605977 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIJ81_RS20230	600599..600868	+	270	WP_044583569.1	DUF1778 domain-containing protein	-
EIJ81_RS20235	600865..601395	+	531	WP_012551863.1	GNAT family N-acetyltransferase	-
EIJ81_RS20240	601404..602099	+	696	WP_012551864.1	hypothetical protein	-
EIJ81_RS20245	602287..602541	+	255	WP_012551865.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EIJ81_RS20250	602532..602846	+	315	WP_012551866.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EIJ81_RS20255	603090..603440	+	351	WP_012551867.1	cupin domain-containing protein	-
EIJ81_RS20260	603680..604150	+	471	WP_012551868.1	hypothetical protein	-
EIJ81_RS20265	604143..604745	+	603	WP_012551869.1	putative adenosine monophosphate-protein transferase Fic	-
EIJ81_RS20275	605437..605706	-	270	WP_012551870.1	type II toxin-antitoxin system YafQ family toxin	Toxin
EIJ81_RS20280	605699..605977	-	279	WP_012551871.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EIJ81_RS20285	606204..607796	-	1593	WP_012551872.1	RNA-directed DNA polymerase	-
EIJ81_RS20295	608365..608559	-	195	WP_012551874.1	hypothetical protein	-
EIJ81_RS23215	608725..608898	+	174	WP_012551875.1	hypothetical protein	-
EIJ81_RS20300	609053..609937	+	885	WP_012551876.1	GIY-YIG nuclease family protein	-
EIJ81_RS20310	610713..610964	+	252	WP_012551877.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	593550..615412	21862

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-84)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10355.92 Da
• Isoelectric Point: 8.9467

>T115589 WP_012551870.1 NZ_CP034241:c605706-605437 [Aliivibrio salmonicida]
MYNLEYSTQFKKDFKKITKMPISNIIEVGNIISKLQRNETLDPKNVDHSLTGNWSGFRDCHIKPDLVLIYRIFDGQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T115589 NZ_CP034241:c605706-605437 [Aliivibrio salmonicida]
ATGTATAACCTAGAATACTCCACGCAATTTAAAAAGGATTTTAAGAAGATAACTAAAATGCCAATCTCCAATATCATCGA
AGTTGGCAATATCATCTCAAAATTACAAAGAAATGAAACATTAGACCCTAAAAATGTAGATCATTCTTTAACGGGAAATT
GGAGTGGTTTTCGCGACTGTCATATAAAACCAGACTTAGTTCTCATTTACCGTATATTTGATGGGCAACTACAACTAGCA
AGAATTGGGTCACATAGCGATCTATTTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10029.47 Da
• Isoelectric Point: 6.2167

>AT115589 WP_012551871.1 NZ_CP034241:c605977-605699 [Aliivibrio salmonicida]
MRNEMLSTRIDHDTKLAFTSICGEVGLSTSQAIKLFAKAVINHGGIPFDLRVPQPNEVSAAAMKELVENKGHKANSIDEM
FSELTEGKVTNV

Nucleotide

• Length: 279 bp

>AT115589 NZ_CP034241:c605977-605699 [Aliivibrio salmonicida]
ATGAGAAATGAAATGCTAAGCACCCGCATAGACCATGATACCAAACTTGCTTTCACTAGCATCTGCGGTGAAGTTGGCCT
AAGCACATCACAAGCAATTAAACTATTTGCTAAAGCTGTCATTAACCATGGTGGTATTCCATTTGATCTACGAGTTCCGC
AGCCAAATGAAGTTTCTGCTGCTGCAATGAAAGAACTTGTTGAAAATAAAGGACATAAAGCCAACTCTATAGATGAGATG
TTTTCTGAGCTCACTGAAGGCAAAGTGACAAATGTATAA

Structures

Toxin

• AlphaFold DB: B6ERG8

Antitoxin

• AlphaFold DB: B6ERG9