Detailed information of TA system TA115587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 600599..601395
• Replicon: chromosome
• Accession: NZ_CP034241
• Organism: Aliivibrio salmonicida strain VS224

Toxin (Protein)

• Gene name: -
• Uniprot ID: B6ERG1
• Locus tag: EIJ81_RS20235
• Protein ID: WP_012551863.1
• Coordinates: 600865..601395 (+)
• Length: 177 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EIJ81_RS20230
• Protein ID: WP_044583569.1
• Coordinates: 600599..600868 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIJ81_RS20215	598106..598861	+	756	WP_012551859.1	membrane protein	-
EIJ81_RS20220	599063..599776	+	714	WP_012551860.1	RES family NAD+ phosphorylase	-
EIJ81_RS20225	599934..600368	+	435	WP_044583568.1	GNAT family N-acetyltransferase	-
EIJ81_RS20230	600599..600868	+	270	WP_044583569.1	DUF1778 domain-containing protein	Antitoxin
EIJ81_RS20235	600865..601395	+	531	WP_012551863.1	GNAT family N-acetyltransferase	Toxin
EIJ81_RS20240	601404..602099	+	696	WP_012551864.1	hypothetical protein	-
EIJ81_RS20245	602287..602541	+	255	WP_012551865.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EIJ81_RS20250	602532..602846	+	315	WP_012551866.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EIJ81_RS20255	603090..603440	+	351	WP_012551867.1	cupin domain-containing protein	-
EIJ81_RS20260	603680..604150	+	471	WP_012551868.1	hypothetical protein	-
EIJ81_RS20265	604143..604745	+	603	WP_012551869.1	putative adenosine monophosphate-protein transferase Fic	-
EIJ81_RS20275	605437..605706	-	270	WP_012551870.1	type II toxin-antitoxin system YafQ family toxin	-
EIJ81_RS20280	605699..605977	-	279	WP_012551871.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	594905..596050	1145
	-	inside	Integron	-	-	593550..615412	21862

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-81)

Sequences

Toxin

Protein

• Length: 177 a.a.
• Molecular weight: 19871.11 Da
• Isoelectric Point: 8.7689

>T115587 WP_012551863.1 NZ_CP034241:600865-601395 [Aliivibrio salmonicida]
VSYSKTFKELDKSQHDRASFDCGEKELNDFIQTQAAKHMQAGISRTMVLPASVPLPNQKYPICSFYSIAPSSISRDTLPQ
AMAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIKALEYLWEINSHMRAYAIVVDCLTEQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Nucleotide

• Length: 531 bp

>T115587 NZ_CP034241:600865-601395 [Aliivibrio salmonicida]
GTGAGTTATTCCAAGACTTTTAAAGAATTGGATAAATCACAACACGATAGAGCATCATTTGACTGCGGTGAAAAAGAGTT
AAATGATTTTATCCAAACTCAAGCCGCTAAACATATGCAAGCAGGTATCAGCCGCACTATGGTTTTGCCTGCTTCTGTGC
CTCTACCAAATCAAAAATATCCAATTTGTTCATTTTATAGTATTGCGCCAAGTTCAATTAGCCGTGATACGTTGCCACAA
GCCATGGCTAAAAAATTACCACGCTATCCAATTCCTGTTTTTCTTTTAGCTCAATTGGCAGTTCATAAAGAATTTCATGG
AAGTGGGTTAGGTAAAGTTAGCTTAATCAAAGCTCTAGAATATCTTTGGGAAATTAACTCTCACATGAGAGCATATGCCA
TTGTTGTTGATTGTTTAACTGAACAAGCTGAGTCATTCTACGCAAAATATGGTTTCGAGGTTCTTTGTGAAATCAATGGT
CGTGTAAGAATGTTCATTCCGATGAAAACAGTCGGTCAGTTATTCACTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9761.17 Da
• Isoelectric Point: 4.3894

>AT115587 WP_044583569.1 NZ_CP034241:600599-600868 [Aliivibrio salmonicida]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTQVISEYESITVEANVFDQFMIACDEAKAPNKALLGAA
AFTKSGEFK

Nucleotide

• Length: 270 bp

>AT115587 NZ_CP034241:600599-600868 [Aliivibrio salmonicida]
ATGGCTACTGCAAGACTTGATATCCGTTTGGATGAAGAAATCAAAGCTAAGGCTGAGAAAGCTTCAGCTTTACTTGGTTT
AAAAAGCTTAACTGAATACGTTGTTCGTTTAATGGACGAAGATTCAACTCAGGTGATTTCTGAATATGAAAGCATCACTG
TTGAAGCAAATGTATTTGACCAATTCATGATTGCTTGTGACGAGGCTAAAGCTCCGAATAAAGCATTACTTGGAGCTGCT
GCATTTACTAAAAGTGGTGAGTTTAAGTGA

Structures

Toxin

• AlphaFold DB: B6ERG1