Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1833996..1835566 Replicon chromosome
Accession NZ_CP034240
Organism Aliivibrio salmonicida strain VS224

Toxin (Protein)


Gene name hipA Uniprot ID B6ENJ7
Locus tag EIJ81_RS10710 Protein ID WP_012550388.1
Coordinates 1834244..1835566 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A839I7G8
Locus tag EIJ81_RS10705 Protein ID WP_023603376.1
Coordinates 1833996..1834244 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIJ81_RS10690 1829411..1831096 + 1686 WP_012550383.1 mechanosensitive ion channel family protein -
EIJ81_RS10695 1831175..1831815 - 641 Protein_1735 LysE family translocator -
EIJ81_RS10700 1832295..1833779 + 1485 WP_012550386.1 carboxypeptidase M32 -
EIJ81_RS10705 1833996..1834244 + 249 WP_023603376.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EIJ81_RS10710 1834244..1835566 + 1323 WP_012550388.1 type II toxin-antitoxin system HipA family toxin Toxin
EIJ81_RS10715 1835729..1837093 - 1365 WP_012550389.1 nucleotidyltransferase -
EIJ81_RS10720 1837097..1838209 - 1113 WP_012550390.1 SAVED domain-containing protein -
EIJ81_RS10725 1838690..1840261 - 1572 WP_012550392.1 cryptochrome/photolyase family protein -
EIJ81_RS10730 1840299..1840439 - 141 WP_083190336.1 DUF2256 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-62)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49428.91 Da        Isoelectric Point: 7.3843

>T115586 WP_012550388.1 NZ_CP034240:1834244-1835566 [Aliivibrio salmonicida]
MAVLIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINYFDNLLPDLSEVRDRIVARYQ
AKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYDVLTPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTAL
LKINDEWCIPKASTPTTHIIKLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEILHCDGIKAIAVERFDRKW
IKNNTKLLRLPQEDMCQAFGLPSSIKYETDGGPSIKTIMDLLMGSSQSLKDRDAFMRFQVFQWLIGATDGHAKNFSIFIN
AQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASKGKKYPIDKIYTRHFIDTAKSVGFDTARMEEIMKEFAINMP
KSIKELEAELPSGFPKDISGSIFSNALRMVNKIRLSNDFQ

Download         Length: 1323 bp

>T115586 NZ_CP034240:1834244-1835566 [Aliivibrio salmonicida]
ATGGCTGTATTAATTGCATACATGAATGGTGAGCGTGTTGGAGAATTTACTAAACTCAGTAACGGTGCACATCAGTTTCA
ATACGATAAATCATGGATAGAAAGTACGGTAGGAAGACCCCTGTCATTATCCCTCCCCCTACAATATCCAAAGATAACCA
GTGATTGCGTTATTAATTACTTCGACAACCTATTACCTGATTTGTCAGAAGTCAGAGATCGCATCGTTGCCAGATACCAA
GCTAAATCTCGTCAAACATTCGATTTACTTCATGAAGTTGGTAAAGACAGCGTCGGTGCTATTTCTTTATTAACTAACGA
TGAAGAACCAAATACCAAACAACTGGATTATGATGTTTTAACTCCAGCACGGCTCAAACAAGTACTCTCAGCCTATCAAT
CCAATATTCCATTAGGAATGCTAGAAGATGAATCAGACTTTCGAATTTCGGTTGCCGGAGCACAAGAAAAAACAGCGTTA
CTCAAAATAAATGATGAATGGTGCATACCGAAAGCATCTACCCCAACAACGCATATAATCAAATTACCCATTGGAAAAAT
TCAACAACCTAATGCCACTCTCGATATGAGTGATAGTGTAGAAAATGAATACCTGTGCATCCAATTAGCTAAGAAGTTAG
GATTCAATGTACCTAATGTTGAAATACTTCATTGTGATGGAATAAAAGCCATTGCTGTAGAACGATTTGATCGAAAGTGG
ATTAAAAATAACACCAAGCTATTAAGATTACCGCAAGAAGATATGTGCCAAGCATTTGGATTACCCTCATCAATCAAATA
TGAAACTGATGGAGGCCCAAGTATAAAAACCATTATGGATCTTCTAATGGGCTCAAGCCAATCACTAAAAGATCGTGATG
CTTTTATGCGATTTCAGGTATTTCAATGGTTAATTGGTGCAACAGACGGACACGCAAAAAACTTCTCCATTTTTATTAAT
GCACAAGGCAGTTATCACCTTACGCCCTTTTATGACATTTTATCCGCCTATCCGATCTTAGGTGGTAAAGGGATGAATAT
CCGCTCATTAAAACTGGCAATGGGACTAACTGCATCAAAAGGAAAGAAATACCCTATTGATAAAATATACACACGTCATT
TTATTGATACGGCTAAATCTGTTGGATTTGATACTGCGAGAATGGAAGAGATAATGAAGGAATTTGCGATAAATATGCCT
AAGTCCATTAAGGAATTAGAAGCAGAATTACCAAGCGGTTTTCCAAAGGATATTTCTGGCAGCATATTCAGTAATGCATT
GAGAATGGTAAATAAGATCCGCTTGAGTAATGATTTTCAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9485.84 Da        Isoelectric Point: 6.4743

>AT115586 WP_023603376.1 NZ_CP034240:1833996-1834244 [Aliivibrio salmonicida]
MIYNPKQLANYLKLIRTKHNLTQTELAKKVGVKQSTLSSFENHPETTQLQTLFKILHALEVHCIIQEQVPTSLDDNPDDE
VW

Download         Length: 249 bp

>AT115586 NZ_CP034240:1833996-1834244 [Aliivibrio salmonicida]
ATGATTTATAATCCAAAACAATTAGCTAACTACTTAAAGCTTATTAGAACCAAACACAACCTGACTCAAACAGAGCTTGC
TAAAAAAGTCGGTGTAAAACAATCCACCCTATCTAGCTTTGAAAATCACCCTGAAACGACTCAGTTACAGACTCTCTTTA
AGATCCTTCATGCGTTAGAAGTTCATTGTATTATTCAAGAGCAAGTCCCAACAAGTCTCGATGATAATCCAGATGATGAG
GTATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6ENJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A839I7G8

References