Detailed information of TA system TA115582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1510789..1511311
• Replicon: chromosome
• Accession: NZ_CP034240
• Organism: Aliivibrio salmonicida strain VS224

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B6EL55
• Locus tag: EIJ81_RS09120
• Protein ID: WP_012535033.1
• Coordinates: 1510789..1511073 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B6EL56
• Locus tag: EIJ81_RS09125
• Protein ID: WP_012550135.1
• Coordinates: 1511063..1511311 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIJ81_RS09095	1507716..1508489	+	774	WP_049940351.1	hypothetical protein	-
EIJ81_RS09100	1508513..1508728	+	216	WP_012550133.1	hypothetical protein	-
EIJ81_RS09105	1508764..1509720	-	957	WP_012549047.1	IS30-like element ISVsa7 family transposase	-
EIJ81_RS09110	1510285..1510467	+	183	Protein_1422	type II toxin-antitoxin system prevent-host-death family antitoxin	-
EIJ81_RS09115	1510464..1510747	+	284	Protein_1423	type II toxin-antitoxin system RelE/ParE family toxin	-
EIJ81_RS09120	1510789..1511073	-	285	WP_012535033.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EIJ81_RS09125	1511063..1511311	-	249	WP_012550135.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EIJ81_RS09130	1511604..1512392	+	789	WP_012550136.1	aminoglycoside phosphotransferase family protein	-
EIJ81_RS09135	1512414..1512866	+	453	WP_012550137.1	NUDIX domain-containing protein	-
EIJ81_RS09140	1512948..1513391	+	444	WP_044583243.1	GNAT family N-acetyltransferase	-
EIJ81_RS09145	1513483..1513578	+	96	Protein_1429	DMT family protein	-
EIJ81_RS09150	1513654..1514244	+	591	WP_049940353.1	outer membrane beta-barrel protein	-
EIJ81_RS09155	1514407..1514802	+	396	WP_044583244.1	hypothetical protein	-
EIJ81_RS09160	1514908..1515914	+	1007	WP_085941784.1	IS630-like element ISVsa8 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11042.98 Da
• Isoelectric Point: 10.5588

>T115582 WP_012535033.1 NZ_CP034240:c1511073-1510789 [Aliivibrio salmonicida]
MTYKLDFKKSAYKEWNKLGATLREQFKKKLLERLDNPHVPASKLSGADNLYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYKKAMHRI

Nucleotide

• Length: 285 bp

>T115582 NZ_CP034240:c1511073-1510789 [Aliivibrio salmonicida]
ATGACTTATAAGTTAGACTTCAAAAAGAGCGCATATAAAGAATGGAATAAACTCGGTGCAACACTTCGTGAGCAATTTAA
GAAAAAGCTATTAGAACGCTTAGATAATCCTCACGTTCCTGCGTCAAAGCTATCAGGCGCTGACAATTTATACAAAATTA
AGCTACGACAGTCTGGTTACCGATTAGTATACAAAGTTGAGGATGACGTAATAATTGTCACCGTTTTAGCTGTTGGCAAA
AGAGAACGCAGCGACGTATACAAAAAAGCGATGCACAGGATTTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9041.23 Da
• Isoelectric Point: 4.0202

>AT115582 WP_012550135.1 NZ_CP034240:c1511311-1511063 [Aliivibrio salmonicida]
MTTRILADVAASITEFKANPMKVASSAYGEAVAILNRNEPAFYCVPAEAYELLLDRVEDLELLSLAAERENEETISVNIH
DL

Nucleotide

• Length: 249 bp

>AT115582 NZ_CP034240:c1511311-1511063 [Aliivibrio salmonicida]
ATGACCACTAGAATTTTAGCCGATGTTGCAGCAAGCATTACCGAGTTTAAAGCTAACCCAATGAAAGTTGCTTCAAGTGC
TTACGGTGAAGCTGTTGCGATACTAAACAGGAATGAGCCTGCATTTTATTGTGTGCCAGCAGAAGCTTATGAACTATTGC
TGGATAGAGTTGAAGATCTAGAACTATTATCCCTTGCCGCAGAACGAGAGAATGAAGAAACTATTTCGGTAAACATCCAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: B6EL55

Antitoxin

• AlphaFold DB: B6EL56