Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4866743..4868328 Replicon chromosome
Accession NZ_CP034237
Organism Pectobacterium carotovorum subsp. carotovorum strain JR1.1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EH204_RS21710 Protein ID WP_161510020.1
Coordinates 4867009..4868328 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EH204_RS21705 Protein ID WP_161510019.1
Coordinates 4866743..4867009 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH204_RS21680 4862377..4863879 - 1503 WP_039475218.1 MFS transporter -
EH204_RS21685 4863983..4864537 + 555 WP_010302412.1 TetR/AcrR family transcriptional regulator -
EH204_RS21690 4864587..4864997 - 411 WP_161510016.1 helix-turn-helix transcriptional regulator -
EH204_RS21695 4865111..4865962 + 852 WP_161510017.1 SDR family oxidoreductase -
EH204_RS21700 4866061..4866582 - 522 WP_161510018.1 hypothetical protein -
EH204_RS21705 4866743..4867009 + 267 WP_161510019.1 helix-turn-helix domain-containing protein Antitoxin
EH204_RS21710 4867009..4868328 + 1320 WP_161510020.1 type II toxin-antitoxin system HipA family toxin Toxin
EH204_RS21715 4868361..4869725 - 1365 WP_039475235.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
EH204_RS21720 4869853..4871487 - 1635 WP_039508244.1 membrane protein insertase YidC -
EH204_RS21725 4871490..4871747 - 258 WP_010302384.1 membrane protein insertion efficiency factor YidD -
EH204_RS21730 4871711..4872070 - 360 WP_010302382.1 ribonuclease P protein component -
EH204_RS21735 4872089..4872229 - 141 WP_005976668.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49269.42 Da        Isoelectric Point: 6.6183

>T115581 WP_161510020.1 NZ_CP034237:4867009-4868328 [Pectobacterium carotovorum subsp. carotovorum]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGTDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILVEFSNTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMRGWE

Download         Length: 1320 bp

>T115581 NZ_CP034237:4867009-4868328 [Pectobacterium carotovorum subsp. carotovorum]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTGGGGATTCTGACCAAAACGGGCAGTGGGGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGATTGCCGGGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGCCCTATCAAG
GTGATGAGGTTTATAATTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGACGCATTGTCGCCAGACATCAC
GCTGACTCCACCCAACCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGTGTCGGGGCGTTGCAATTAGTGCCGCAGGG
TACACCTGTGCACGATATAAAAAAGATCGAATACAAAACCTTATCCGAGCAGCAGCTTGAAAACATACTGACCGGATATC
TGTCCGATGCCCCGCTGGGTATGATTGATACTGAAGACGATTTTCGTATTTCTATCGCAGGTGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGATCACTGGTGCCTGCCTCTCAATGCCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGTTTGCTCATTGCCAAGGCAT
TTGGGCTGCCAGTGCCGCACTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGCTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGTTCGGTTGATCCAGAAAGAGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCCTGTTTATT
GAATCTGAGGGGCGATATCGACTCACACCTTTCTATGACATTCTCTCTATGTATCCGGCGATGGGCGGACGGGGAACTGA
CCGCAGAGAGGCCAAACTGGCGATGGGATTAACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTTCCCCGAC
ATTTTTTCCAGACGGCTAAGGCCGTTGGGTTTGCCAGAGAATCGATGGAAAACATTCTGGTGGAGTTTTCAAACACCGTT
GAGACCGTTATGACGACTGTTGGAAGCCAACTGCCTGTGGATTTTCCTACTCATATCAGTGAGGCAATTCTGGCCGGATT
GCAGGCCAGATCGAGACGGCTCATGAGAGGATGGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9930.18 Da        Isoelectric Point: 9.7281

>AT115581 WP_161510019.1 NZ_CP034237:4866743-4867009 [Pectobacterium carotovorum subsp. carotovorum]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDNTNNEASV
ASSWKEEW

Download         Length: 267 bp

>AT115581 NZ_CP034237:4866743-4867009 [Pectobacterium carotovorum subsp. carotovorum]
ATGAAGGTCACCAACAGCAAGCAGCTTAGCAGCTACCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGCTTCGAGCAACATCCTGATTCCACCAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTGAACTTAGAACTTACTGTTACGCCCAGGAATGTGGACAACACCAATAATGAAGCCTCTGTT
GCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References