Detailed information of TA system TA115580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4716887..4717422
• Replicon: chromosome
• Accession: NZ_CP034237
• Organism: Pectobacterium carotovorum subsp. carotovorum strain JR1.1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EH204_RS21070
• Protein ID: WP_161509987.1
• Coordinates: 4717135..4717422 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q6DB37
• Locus tag: EH204_RS21065
• Protein ID: WP_010281712.1
• Coordinates: 4716887..4717138 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EH204_RS21045	4713350..4713787	+	438	WP_010296551.1	RICIN domain-containing protein	-
EH204_RS21050	4714032..4714655	-	624	WP_161509986.1	LysE family translocator	-
EH204_RS21055	4714934..4715689	+	756	WP_161503008.1	thiol:disulfide interchange protein DsbG	-
EH204_RS21060	4715724..4716629	-	906	WP_029367632.1	siderophore-interacting protein	-
EH204_RS21065	4716887..4717138	+	252	WP_010281712.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EH204_RS21070	4717135..4717422	+	288	WP_161509987.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EH204_RS21075	4717524..4718876	-	1353	WP_010296544.1	glutathione-disulfide reductase	-
EH204_RS21080	4719005..4719847	-	843	WP_010296540.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
EH204_RS21085	4720129..4720512	-	384	WP_161509988.1	TfoX/Sxy family protein	-
EH204_RS21090	4720635..4721990	-	1356	WP_161509989.1	alkyl/aryl-sulfatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11158.34 Da
• Isoelectric Point: 10.5828

>T115580 WP_161509987.1 NZ_CP034237:4717135-4717422 [Pectobacterium carotovorum subsp. carotovorum]
MSYRVKFREDALKEWLKLDKAIQQQFAKKLKKCCENPHIPAAKLRGMKNCYKIKLRTSGFRLVYEVIDDVLIIAMVAVGK
RERSGVYHLASERMR

Nucleotide

• Length: 288 bp

>T115580 NZ_CP034237:4717135-4717422 [Pectobacterium carotovorum subsp. carotovorum]
ATGAGTTATCGCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGCTAAAACTCGATAAAGCTATCCAACAACAATTCGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTGCGGCAAAGTTACGGGGGATGAAGAATTGCTACAAAATAA
AGCTCCGAACGTCAGGCTTTCGTTTGGTTTACGAGGTTATTGACGACGTATTGATTATCGCCATGGTGGCGGTAGGCAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGCGAGTGAGCGAATGAGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9117.47 Da
• Isoelectric Point: 4.0637

>AT115580 WP_010281712.1 NZ_CP034237:4716887-4717138 [Pectobacterium carotovorum subsp. carotovorum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Nucleotide

• Length: 252 bp

>AT115580 NZ_CP034237:4716887-4717138 [Pectobacterium carotovorum subsp. carotovorum]
ATGCCAAATATTATATTGAGTGATACCAGTGCTAGCGTCAGTGAACTGAAAAAGAACCCGATGGCGACGGTCAATGCTGG
TGATGGCCTGCCCGTCGCTATCTTGAACCGCAACCAACCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTGGTGAAACTGATCGGTGAACGAAAAAACCAGCCGCTGGTTGACGTGGATTTGGAT
AGTTTCCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0M2EZP0