Detailed information of TA system TA115568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-DnaT
• Location: 366528..367059
• Replicon: chromosome
• Accession: NZ_CP034237
• Organism: Pectobacterium carotovorum subsp. carotovorum strain JR1.1

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: EH204_RS01650
• Protein ID: WP_161508693.1
• Coordinates: 366772..367059 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: A0A1V2R9J2
• Locus tag: EH204_RS01645
• Protein ID: WP_039282788.1
• Coordinates: 366528..366782 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EH204_RS01620	361860..362450	-	591	WP_005975525.1	DnaA initiator-associating protein DiaA	-
EH204_RS01625	362639..362995	-	357	WP_202618447.1	YraN family protein	-
EH204_RS01630	362992..365010	-	2019	WP_010296721.1	penicillin-binding protein activator	-
EH204_RS01635	365072..365959	+	888	WP_039507283.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
EH204_RS01645	366528..366782	+	255	WP_039282788.1	plasmid stabilization protein	Antitoxin
EH204_RS01650	366772..367059	+	288	WP_161508693.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EH204_RS01655	367235..368020	+	786	WP_161508694.1	4,5-DOPA dioxygenase extradiol	-
EH204_RS01660	368280..369440	-	1161	WP_010297418.1	glutathionylspermidine synthase family protein	-
EH204_RS01665	369451..370125	-	675	WP_010297420.1	DUF1190 family protein	-
EH204_RS01670	370396..371790	-	1395	WP_010297423.1	outer membrane channel protein TolC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11011.92 Da
• Isoelectric Point: 10.7148

>T115568 WP_161508693.1 NZ_CP034237:366772-367059 [Pectobacterium carotovorum subsp. carotovorum]
MTYKLKFVPSAMKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTQGRSA

Nucleotide

• Length: 288 bp

>T115568 NZ_CP034237:366772-367059 [Pectobacterium carotovorum subsp. carotovorum]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAATTAGGACACCCTGTCCGGGAGCAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAAATCCTCGTGTTCCTTCAGCCCAACTTCATGGCCGTAAAGACCAGTATAAAATTA
AACTGAAGTCCGCTGGCTACAGGCTGGTGTATTTGGTCCAGGATGAGACCATTACTGTGATGGTTATGGGCGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACTCAAGGTCGCTCTGCTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9208.38 Da
• Isoelectric Point: 3.7947

>AT115568 WP_039282788.1 NZ_CP034237:366528-366782 [Pectobacterium carotovorum subsp. carotovorum]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
LDDL

Nucleotide

• Length: 255 bp

>AT115568 NZ_CP034237:366528-366782 [Pectobacterium carotovorum subsp. carotovorum]
ATGGCTTTCAACATCCTGACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTACGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCGGCGTTCTACTGTGTGCCTCCTGCCGTATTCGCTTATTTAA
TGGAACTGGCTGAAGATGCCGAACTGGGGCGTACTGTTGATGATCGGATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1V2R9J2