Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 201975..202592 Replicon chromosome
Accession NZ_CP034237
Organism Pectobacterium carotovorum subsp. carotovorum strain JR1.1

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag EH204_RS00870 Protein ID WP_010281507.1
Coordinates 202413..202592 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A426IL41
Locus tag EH204_RS00865 Protein ID WP_039545938.1
Coordinates 201975..202385 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH204_RS00850 197840..198883 - 1044 WP_010281514.1 DNA-binding transcriptional regulator CytR -
EH204_RS00855 199193..201391 - 2199 WP_161508663.1 primosomal protein N' -
EH204_RS00860 201663..201878 + 216 WP_010281510.1 50S ribosomal protein L31 -
EH204_RS00865 201975..202385 - 411 WP_039545938.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EH204_RS00870 202413..202592 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
EH204_RS00875 202692..203702 - 1011 WP_039508126.1 iron ABC transporter permease -
EH204_RS00880 203699..204661 - 963 WP_161510027.1 ABC transporter substrate-binding protein -
EH204_RS00885 204671..205468 - 798 WP_010299273.1 ABC transporter ATP-binding protein -
EH204_RS00890 205686..206003 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
EH204_RS00895 206191..207351 + 1161 WP_010299271.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T115567 WP_010281507.1 NZ_CP034237:c202592-202413 [Pectobacterium carotovorum subsp. carotovorum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T115567 NZ_CP034237:c202592-202413 [Pectobacterium carotovorum subsp. carotovorum]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTAAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGGTTAGTCACCATCCCCCACCCGAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14533.41 Da        Isoelectric Point: 4.3391

>AT115567 WP_039545938.1 NZ_CP034237:c202385-201975 [Pectobacterium carotovorum subsp. carotovorum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT115567 NZ_CP034237:c202385-201975 [Pectobacterium carotovorum subsp. carotovorum]
ATGTTTTATCCGATTGCAATTGAAGCAGGCGACGATACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTGATCGAGA
TGGGTCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTGGCAAAAAACGCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATTGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAATGTCACGCTGCCTAAGTCGCTGATTGATCGCAT
TGATCGTTGCGTGGCGAGTAACCCAGAATTTAAAAGTCGTTCGGGTTTTCTCGCACAGGCGGCATTAGAACGAATCTCGT
CTTCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure
AlphaFold DB A0A426IL41

References