Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4276279..4276862 Replicon chromosome
Accession NZ_CP034236
Organism Pectobacterium carotovorum subsp. carotovorum strain BP201601.1

Toxin (Protein)


Gene name parE Uniprot ID A0A7V8PTK4
Locus tag EH203_RS19135 Protein ID WP_010296214.1
Coordinates 4276279..4276584 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7V8PT23
Locus tag EH203_RS19140 Protein ID WP_010296210.1
Coordinates 4276572..4276862 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH203_RS19120 4272638..4273597 + 960 WP_029367586.1 ABC transporter permease -
EH203_RS19125 4273590..4274456 + 867 WP_010296221.1 ABC transporter permease -
EH203_RS19130 4274453..4276159 + 1707 WP_161502916.1 ABC transporter ATP-binding protein -
EH203_RS19135 4276279..4276584 - 306 WP_010296214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EH203_RS19140 4276572..4276862 - 291 WP_010296210.1 ribbon-helix-helix protein, CopG family Antitoxin
EH203_RS19145 4276924..4277778 - 855 WP_029367584.1 helix-turn-helix domain-containing protein -
EH203_RS19150 4277803..4278642 - 840 WP_010296204.1 HTH-type transcriptional activator RhaS -
EH203_RS19155 4278979..4280469 + 1491 WP_010296202.1 rhamnulokinase -
EH203_RS19160 4280466..4281728 + 1263 WP_010296200.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11576.44 Da        Isoelectric Point: 9.8325

>T115564 WP_010296214.1 NZ_CP034236:c4276584-4276279 [Pectobacterium carotovorum subsp. carotovorum]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTGRVVILTVKHQKEAGYQNP

Download         Length: 306 bp

>T115564 NZ_CP034236:c4276584-4276279 [Pectobacterium carotovorum subsp. carotovorum]
ATGCCACAAGTGATCGTTTCAGAACGCGCGAGGCGTGATTTGCAGCGTCTACAGGATTTTCTAAAAAACAAAAATGCGCT
GGCCGCGAAAAAGGCCGCTGAAGTTTTGATTCGGGGCATTCGTCAGTTAGAAGCGCTGCCGAATATCGGGCGACCAGTGG
AACATCTTCCCCTTGAATATCAAGAGTTGGTGATCGAATTCGGCAGCAGCGGGTATGTGATGCTTTACCGTCACGATGAG
CTGACCGGCAGAGTGGTGATACTGACCGTTAAACATCAAAAAGAAGCTGGTTATCAAAACCCGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11064.13 Da        Isoelectric Point: 4.7692

>AT115564 WP_010296210.1 NZ_CP034236:c4276862-4276572 [Pectobacterium carotovorum subsp. carotovorum]
MADTTRQTTTLRIDQDIKERLKTLADDRNSSAHALMLEAIAEYVEREEKRSQYRKEALAAWEDYQDTGKHITADETVTWL
ESWGSGHEQDAPACHK

Download         Length: 291 bp

>AT115564 NZ_CP034236:c4276862-4276572 [Pectobacterium carotovorum subsp. carotovorum]
ATGGCTGACACCACACGTCAAACCACGACGCTGCGCATCGATCAGGACATTAAAGAACGACTGAAAACGCTGGCCGATGA
CCGCAACAGCTCAGCCCATGCGCTGATGCTGGAAGCGATTGCCGAATACGTTGAACGGGAAGAAAAACGCAGCCAGTACC
GTAAAGAGGCGTTGGCCGCGTGGGAAGACTATCAGGACACTGGCAAACATATCACCGCAGATGAGACCGTTACCTGGTTA
GAATCCTGGGGTTCTGGACATGAACAGGATGCGCCTGCATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8PTK4

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8PT23

References