Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3537704..3538329 Replicon chromosome
Accession NZ_CP034236
Organism Pectobacterium carotovorum subsp. carotovorum strain BP201601.1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag EH203_RS15960 Protein ID WP_005976087.1
Coordinates 3538126..3538329 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag EH203_RS15955 Protein ID WP_005976089.1
Coordinates 3537704..3538072 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH203_RS15940 3533348..3536476 + 3129 WP_010303023.1 multidrug efflux RND transporter permease subunit -
EH203_RS15945 3536695..3536943 + 249 WP_010303021.1 type B 50S ribosomal protein L31 -
EH203_RS15950 3536961..3537104 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
EH203_RS15955 3537704..3538072 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
EH203_RS15960 3538126..3538329 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
EH203_RS15970 3539073..3539393 + 321 WP_010282239.1 MGMT family protein -
EH203_RS15975 3539413..3539994 - 582 WP_010303016.1 YbaY family lipoprotein -
EH203_RS15980 3540207..3541070 + 864 WP_161502770.1 acyl-CoA thioesterase II -
EH203_RS15985 3541207..3542493 - 1287 WP_039472387.1 ammonium transporter AmtB -
EH203_RS15990 3542533..3542871 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T115560 WP_005976087.1 NZ_CP034236:3538126-3538329 [Pectobacterium carotovorum subsp. carotovorum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T115560 NZ_CP034236:3538126-3538329 [Pectobacterium carotovorum subsp. carotovorum]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGTCTGGCTGAACTGACGATGAACAAAC
TCTACGACAAAGTCCCTACTGCAGTATGGCGATACGTTCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT115560 WP_005976089.1 NZ_CP034236:3537704-3538072 [Pectobacterium carotovorum subsp. carotovorum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT115560 NZ_CP034236:3537704-3538072 [Pectobacterium carotovorum subsp. carotovorum]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
GACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGCATTAATGATGCTGAACTACGGCGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References