Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 195517..196134 Replicon chromosome
Accession NZ_CP034236
Organism Pectobacterium carotovorum subsp. carotovorum strain BP201601.1

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag EH203_RS00840 Protein ID WP_010281507.1
Coordinates 195955..196134 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7T5QP09
Locus tag EH203_RS00835 Protein ID WP_010299285.1
Coordinates 195517..195927 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH203_RS00820 191382..192425 - 1044 WP_010299291.1 DNA-binding transcriptional regulator CytR -
EH203_RS00825 192734..194932 - 2199 WP_010299288.1 primosomal protein N' -
EH203_RS00830 195205..195420 + 216 WP_010281510.1 50S ribosomal protein L31 -
EH203_RS00835 195517..195927 - 411 WP_010299285.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EH203_RS00840 195955..196134 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
EH203_RS00845 196234..197243 - 1010 Protein_167 iron ABC transporter permease -
EH203_RS00850 197240..198202 - 963 WP_010299277.1 ABC transporter substrate-binding protein -
EH203_RS00855 198212..199009 - 798 WP_010299273.1 ABC transporter ATP-binding protein -
EH203_RS00860 199227..199544 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
EH203_RS00865 199732..200892 + 1161 WP_010299271.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T115555 WP_010281507.1 NZ_CP034236:c196134-195955 [Pectobacterium carotovorum subsp. carotovorum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T115555 NZ_CP034236:c196134-195955 [Pectobacterium carotovorum subsp. carotovorum]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAGCTGATAAGAGTAAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGGTTAGTCACCATCCCCCACCCGAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14549.41 Da        Isoelectric Point: 4.3391

>AT115555 WP_010299285.1 NZ_CP034236:c195927-195517 [Pectobacterium carotovorum subsp. carotovorum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT115555 NZ_CP034236:c195927-195517 [Pectobacterium carotovorum subsp. carotovorum]
ATGTTTTATCCGATTGCAATTGAAGCAGGCGACGATACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTGATCGAGA
TGGGTCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTAGCAAAAAACTCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATTGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAACGTCACGCTGCCTAAGTCGCTGATTGACCGCAT
TGATCGTTGCGTGGCGAGTAACCCAGAATTTAAAAGTCGTTCGGGTTTTCTCGCACAGGCGGCATTAGAACGAATCTCGT
CTTCTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure
AlphaFold DB A0A7T5QP09

References