Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 6183531..6184136 Replicon chromosome
Accession NZ_CP034235
Organism Paenibacillus psychroresistens strain ML311-T8

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EHS13_RS28060 Protein ID WP_155703549.1
Coordinates 6183531..6183881 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EHS13_RS28065 Protein ID WP_193571557.1
Coordinates 6183885..6184136 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHS13_RS28040 6179456..6179932 - 477 WP_155703545.1 SprT family protein -
EHS13_RS28045 6180087..6180446 + 360 WP_155703546.1 hydrolase/acyltransferase -
EHS13_RS28050 6180549..6180698 + 150 WP_155703547.1 cortex morphogenetic protein CmpA -
EHS13_RS28055 6181046..6183346 - 2301 WP_155703548.1 RNA-binding transcriptional accessory protein -
EHS13_RS28060 6183531..6183881 - 351 WP_155703549.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EHS13_RS28065 6183885..6184136 - 252 WP_193571557.1 ribbon-helix-helix protein, CopG family Antitoxin
EHS13_RS28070 6184337..6185515 - 1179 WP_155703551.1 alanine racemase -
EHS13_RS28075 6185654..6186964 - 1311 WP_155703552.1 outer membrane lipoprotein carrier protein LolA -
EHS13_RS28080 6187228..6187731 + 504 WP_155703553.1 hypothetical protein -
EHS13_RS28085 6187740..6188321 - 582 WP_155703554.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-35)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12906.84 Da        Isoelectric Point: 4.8837

>T115553 WP_155703549.1 NZ_CP034235:c6183881-6183531 [Paenibacillus psychroresistens]
MIVKRGDVFFAELSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAETHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDETMRKVDEGLQISVGLIDF

Download         Length: 351 bp

>T115553 NZ_CP034235:c6183881-6183531 [Paenibacillus psychroresistens]
TTGATTGTTAAACGTGGCGATGTGTTTTTTGCAGAGTTGTCTCCTGTGGTCGGTTCTGAGCAAGGAGGCGTTCGACCGGT
ATTGATTATTCAGAATGATATTGGAAATCGCTTCAGCCCTACTGTAATTATTGCCGCAATTACGGCACAAATTCAAAAAG
CAAAGCTGCCTACACATGTGGAAATTGATGCAGAAACACATGGCTTTGATCGTGATTCCGTTATTCTGCTGGAACAAATT
AGAACCATCGATAAACAACGCTTAACGGATAAAATTACTCATCTCGATGATGAAACGATGCGTAAGGTAGATGAAGGCTT
ACAAATTAGTGTGGGCTTGATTGATTTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9594.10 Da        Isoelectric Point: 6.4702

>AT115553 WP_193571557.1 NZ_CP034235:c6184136-6183885 [Paenibacillus psychroresistens]
MISLPDHLLQEVDGIVEKENSNRSEFIRQAMKLYLMERKKRVLRESMQRGYMEMAKINLHIALEAFQAEEDAGSTVNRLV
SGV

Download         Length: 252 bp

>AT115553 NZ_CP034235:c6184136-6183885 [Paenibacillus psychroresistens]
ATGATCAGTCTACCAGACCATTTATTGCAAGAAGTCGATGGGATTGTAGAGAAAGAAAACTCCAATCGCAGTGAGTTTAT
TCGGCAAGCTATGAAGCTTTATTTGATGGAACGTAAAAAAAGAGTGCTCCGTGAATCCATGCAGCGCGGCTATATGGAAA
TGGCCAAAATCAATTTACACATTGCTTTGGAAGCATTTCAAGCTGAGGAAGACGCTGGAAGCACTGTGAACCGTTTAGTT
AGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References