Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3874205..3874856 Replicon chromosome
Accession NZ_CP034213
Organism Escherichia albertii strain NCTC 9362

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag DSB70_RS19900 Protein ID WP_125060506.1
Coordinates 3874452..3874856 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag DSB70_RS19895 Protein ID WP_000354046.1
Coordinates 3874205..3874471 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSB70_RS19870 3869809..3871242 - 1434 WP_164474096.1 6-phospho-beta-glucosidase BglA -
DSB70_RS19875 3871287..3871598 + 312 WP_098401332.1 N(4)-acetylcytidine aminohydrolase -
DSB70_RS19880 3871766..3872425 + 660 WP_000250281.1 hemolysin III family protein -
DSB70_RS24565 3872483..3872661 + 179 Protein_3868 hypothetical protein -
DSB70_RS19885 3872973..3873953 - 981 WP_125060505.1 tRNA-modifying protein YgfZ -
DSB70_RS19890 3873985..3874215 + 231 WP_000181267.1 hypothetical protein -
DSB70_RS19895 3874205..3874471 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
DSB70_RS19900 3874452..3874856 + 405 WP_125060506.1 protein YgfX Toxin
DSB70_RS19905 3874895..3875416 - 522 WP_125060507.1 flavodoxin FldB -
DSB70_RS19910 3875528..3876424 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
DSB70_RS19915 3876449..3877159 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DSB70_RS19920 3877165..3878898 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15901.81 Da        Isoelectric Point: 11.1732

>T115532 WP_125060506.1 NZ_CP034213:3874452-3874856 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKNGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T115532 NZ_CP034213:3874452-3874856 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAAATGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT115532 WP_000354046.1 NZ_CP034213:3874205-3874471 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT115532 NZ_CP034213:3874205-3874471 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCATT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAGTGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References