Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1825706..1826324 Replicon chromosome
Accession NZ_CP034213
Organism Escherichia albertii strain NCTC 9362

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DSB70_RS09490 Protein ID WP_001280991.1
Coordinates 1826106..1826324 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag DSB70_RS09485 Protein ID WP_000344798.1
Coordinates 1825706..1826080 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSB70_RS09475 (1820786) 1820786..1821979 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DSB70_RS09480 (1822002) 1822002..1825151 + 3150 WP_125059850.1 efflux RND transporter permease AcrB -
DSB70_RS09485 (1825706) 1825706..1826080 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
DSB70_RS09490 (1826106) 1826106..1826324 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DSB70_RS09495 (1826501) 1826501..1827058 + 558 WP_025237467.1 maltose O-acetyltransferase -
DSB70_RS09500 (1827165) 1827165..1827635 + 471 WP_000136188.1 YlaC family protein -
DSB70_RS09505 (1827799) 1827799..1829349 + 1551 Protein_1852 EAL domain-containing protein -
DSB70_RS09510 (1829387) 1829387..1829740 - 354 WP_000878151.1 DUF1428 family protein -
DSB70_RS09520 (1830121) 1830121..1830432 + 312 WP_000409915.1 MGMT family protein -
DSB70_RS09525 (1830462) 1830462..1831034 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T115523 WP_001280991.1 NZ_CP034213:1826106-1826324 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T115523 NZ_CP034213:1826106-1826324 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT115523 WP_000344798.1 NZ_CP034213:1825706-1826080 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT115523 NZ_CP034213:1825706-1826080 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References