Detailed information of TA system TA115522

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1365676..1366471
• Replicon: chromosome
• Accession: NZ_CP034213
• Organism: Escherichia albertii strain NCTC 9362

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: DSB70_RS07115
• Protein ID: WP_125059712.1
• Coordinates: 1365676..1366050 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7UP42
• Locus tag: DSB70_RS07120
• Protein ID: WP_001280955.1
• Coordinates: 1366097..1366471 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSB70_RS07085 (1362127)	1362127..1362831	+	705	WP_059235232.1	leucyl/phenylalanyl-tRNA--protein transferase	-
DSB70_RS07090 (1363116)	1363116..1363334	+	219	WP_001040187.1	translation initiation factor IF-1	-
DSB70_RS07100 (1364052)	1364052..1364894	-	843	WP_001280481.1	DUF4942 domain-containing protein	-
DSB70_RS07105 (1364979)	1364979..1365176	-	198	WP_000839282.1	DUF957 domain-containing protein	-
DSB70_RS07110 (1365188)	1365188..1365679	-	492	WP_125059711.1	DUF5983 family protein	-
DSB70_RS07115 (1365676)	1365676..1366050	-	375	WP_125059712.1	TA system toxin CbtA family protein	Toxin
DSB70_RS07120 (1366097)	1366097..1366471	-	375	WP_001280955.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DSB70_RS24070 (1366496)	1366496..1366663	-	168	WP_241201521.1	hypothetical protein	-
DSB70_RS07125 (1366610)	1366610..1367259	+	650	WP_152065544.1	IS1 family transposase	-
DSB70_RS07130 (1367329)	1367329..1368326	-	998	Protein_1403	IS3 family transposase	-
DSB70_RS07135 (1368712)	1368712..1369905	-	1194	WP_125059713.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14147.20 Da
• Isoelectric Point: 7.7761

>T115522 WP_125059712.1 NZ_CP034213:c1366050-1365676 [Escherichia albertii]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRTRRATGLMTRDNYRTVNNITLGKYPEAK

Nucleotide

• Length: 375 bp

>T115522 NZ_CP034213:c1366050-1365676 [Escherichia albertii]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTACTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGACTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13767.59 Da
• Isoelectric Point: 6.6248

>AT115522 WP_001280955.1 NZ_CP034213:c1366471-1366097 [Escherichia albertii]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Nucleotide

• Length: 375 bp

>AT115522 NZ_CP034213:c1366471-1366097 [Escherichia albertii]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U9P0D0