Detailed information of TA system TA115521

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1264395..1264876
• Replicon: chromosome
• Accession: NZ_CP034213
• Organism: Escherichia albertii strain NCTC 9362

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: DSB70_RS06685
• Protein ID: WP_021568727.1
• Coordinates: 1264586..1264876 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: DSB70_RS06680
• Protein ID: WP_000108762.1
• Coordinates: 1264395..1264586 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSB70_RS06645 (1259683)	1259683..1260453	-	771	WP_125059683.1	DUF1627 domain-containing protein	-
DSB70_RS06650 (1260475)	1260475..1261221	-	747	WP_125059684.1	ATP-binding protein	-
DSB70_RS06655 (1261228)	1261228..1262343	-	1116	WP_125059685.1	DNA-binding protein	-
DSB70_RS06660 (1262422)	1262422..1262877	+	456	WP_125059686.1	hypothetical protein	-
DSB70_RS06665 (1263084)	1263084..1263509	-	426	WP_021568729.1	toxin YdaT family protein	-
DSB70_RS06670 (1263506)	1263506..1263769	-	264	WP_001048459.1	helix-turn-helix transcriptional regulator	-
DSB70_RS06675 (1263877)	1263877..1264377	+	501	WP_021568728.1	helix-turn-helix transcriptional regulator	-
DSB70_RS06680 (1264395)	1264395..1264586	+	192	WP_000108762.1	hypothetical protein	Antitoxin
DSB70_RS06685 (1264586)	1264586..1264876	+	291	WP_021568727.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DSB70_RS06690 (1265151)	1265151..1265303	+	153	WP_000367377.1	DUF1391 family protein	-
DSB70_RS06695 (1265315)	1265315..1265953	+	639	WP_000394543.1	hypothetical protein	-
DSB70_RS06700 (1265954)	1265954..1266163	-	210	WP_001133037.1	hypothetical protein	-
DSB70_RS06705 (1266731)	1266731..1266919	+	189	WP_000413705.1	cell division inhibition protein DicB	-
DSB70_RS06710 (1266916)	1266916..1267041	+	126	Protein_1319	DUF1482 family protein	-
DSB70_RS24065 (1267809)	1267809..1267883	+	75	Protein_1321	DUF1482 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1267056..1267559	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11105.96 Da
• Isoelectric Point: 9.9854

>T115521 WP_021568727.1 NZ_CP034213:1264586-1264876 [Escherichia albertii]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLSEHPYLYPPSERALGLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKSC

Nucleotide

• Length: 291 bp

>T115521 NZ_CP034213:1264586-1264876 [Escherichia albertii]
ATGCTGCCCATTTTATGGCTACCTTCTGCGCGTGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTTCTGAACACCCTTACCTGTATCCACCAAGCG
AAAGAGCTCTAGGCCTTCGTGAGATAGTGACCCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7075.91 Da
• Isoelectric Point: 4.0270

>AT115521 WP_000108762.1 NZ_CP034213:1264395-1264586 [Escherichia albertii]
MSTVLSPIISEFETIEQENSYNEWLRTKVAASLADPRPAIPHDEVMAEMENLIAQIASTNRSE

Nucleotide

• Length: 192 bp

>AT115521 NZ_CP034213:1264395-1264586 [Escherichia albertii]
ATGAGTACAGTCCTTTCCCCGATAATTTCAGAATTTGAAACAATCGAACAAGAAAACAGCTATAACGAATGGTTACGCAC
CAAAGTGGCAGCAAGCCTCGCAGACCCCCGTCCTGCAATTCCGCATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CGCAAATAGCTTCGACGAACAGGAGTGAGTAA