Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3491645..3492296 Replicon chromosome
Accession NZ_CP034212
Organism Escherichia albertii strain 2010C-3449

Toxin (Protein)


Gene name cptA Uniprot ID A0A8D9PM36
Locus tag CCF17_RS17930 Protein ID WP_044714929.1
Coordinates 3491892..3492296 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CCF17_RS17925 Protein ID WP_000354046.1
Coordinates 3491645..3491911 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF17_RS17900 (3487476) 3487476..3488909 - 1434 WP_241201703.1 6-phospho-beta-glucosidase BglA -
CCF17_RS17905 (3488954) 3488954..3489265 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
CCF17_RS17910 (3489433) 3489433..3490092 + 660 WP_000250281.1 hemolysin III family protein -
CCF17_RS17915 (3490413) 3490413..3491393 - 981 WP_151401906.1 tRNA-modifying protein YgfZ -
CCF17_RS17920 (3491425) 3491425..3491655 + 231 WP_151401907.1 hypothetical protein -
CCF17_RS17925 (3491645) 3491645..3491911 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CCF17_RS17930 (3491892) 3491892..3492296 + 405 WP_044714929.1 protein YgfX Toxin
CCF17_RS17935 (3492335) 3492335..3492856 - 522 WP_059221135.1 flavodoxin FldB -
CCF17_RS17940 (3492968) 3492968..3493864 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CCF17_RS17945 (3493889) 3493889..3494599 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CCF17_RS17950 (3494605) 3494605..3496338 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15835.76 Da        Isoelectric Point: 10.2082

>T115501 WP_044714929.1 NZ_CP034212:3491892-3492296 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLCLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T115501 NZ_CP034212:3491892-3492296 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGTGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT115501 WP_000354046.1 NZ_CP034212:3491645-3491911 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT115501 NZ_CP034212:3491645-3491911 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References