Detailed information of TA system TA115500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2880766..2881566
• Replicon: chromosome
• Accession: NZ_CP034212
• Organism: Escherichia albertii strain 2010C-3449

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: A0A8H9C5V7
• Locus tag: CCF17_RS14730
• Protein ID: WP_000342455.1
• Coordinates: 2881039..2881566 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: B1EHP0
• Locus tag: CCF17_RS14725
• Protein ID: WP_001277106.1
• Coordinates: 2880766..2881032 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF17_RS14695 (2875850)	2875850..2876547	+	698	WP_225520032.1	IS1-like element IS1A family transposase	-
CCF17_RS14700 (2876541)	2876541..2877341	-	801	WP_151401699.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
CCF17_RS14705 (2877334)	2877334..2878080	-	747	WP_000151888.1	PTS sugar transporter subunit IIC	-
CCF17_RS14710 (2878097)	2878097..2878582	-	486	WP_151401700.1	PTS sugar transporter subunit IIB	-
CCF17_RS14715 (2878589)	2878589..2878990	-	402	WP_001071334.1	PTS sugar transporter subunit IIA	-
CCF17_RS14720 (2879513)	2879513..2880616	+	1104	WP_151401701.1	branched chain amino acid ABC transporter substrate-binding protein LivJ	-
CCF17_RS14725 (2880766)	2880766..2881032	+	267	WP_001277106.1	type II toxin-antitoxin system antitoxin AtaR	Antitoxin
CCF17_RS14730 (2881039)	2881039..2881566	+	528	WP_000342455.1	type II toxin-antitoxin system toxin acetyltransferase AtaT	Toxin
CCF17_RS14735 (2881563)	2881563..2881946	-	384	WP_151401702.1	aspartate 1-decarboxylase autocleavage activator PanM	-
CCF17_RS14740 (2882370)	2882370..2883479	+	1110	WP_151401703.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
CCF17_RS14745 (2883527)	2883527..2884453	+	927	WP_151401704.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
CCF17_RS14750 (2884450)	2884450..2885727	+	1278	WP_059225128.1	branched chain amino acid ABC transporter permease LivM	-
CCF17_RS14755 (2885724)	2885724..2886491	+	768	WP_151401705.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (90-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19607.47 Da
• Isoelectric Point: 6.6343

>T115500 WP_000342455.1 NZ_CP034212:2881039-2881566 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Nucleotide

• Length: 528 bp

>T115500 NZ_CP034212:2881039-2881566 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9942.37 Da
• Isoelectric Point: 10.0863

>AT115500 WP_001277106.1 NZ_CP034212:2880766-2881032 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Nucleotide

• Length: 267 bp

>AT115500 NZ_CP034212:2880766-2881032 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z8E004