Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 705132..705603 Replicon chromosome
Accession NZ_CP034212
Organism Escherichia albertii strain 2010C-3449

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag CCF17_RS03785 Protein ID WP_001303511.1
Coordinates 705325..705603 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag CCF17_RS03780 Protein ID WP_001302048.1
Coordinates 705132..705323 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF17_RS03735 (700194) 700194..700691 - 498 Protein_729 ead/Ea22-like family protein -
CCF17_RS03740 (700688) 700688..700984 - 297 WP_151401098.1 DUF4406 domain-containing protein -
CCF17_RS03745 (700981) 700981..701373 - 393 WP_151401099.1 DUF977 family protein -
CCF17_RS03750 (701389) 701389..702159 - 771 WP_151401100.1 DUF1627 domain-containing protein -
CCF17_RS03755 (702185) 702185..702926 - 742 Protein_733 ATP-binding protein -
CCF17_RS03760 (702933) 702933..703895 - 963 WP_151401101.1 helix-turn-helix domain-containing protein -
CCF17_RS03765 (703918) 703918..704343 - 426 WP_000693943.1 toxin YdaT family protein -
CCF17_RS03770 (704340) 704340..704642 - 303 WP_000172738.1 transcriptional regulator -
CCF17_RS03775 (704740) 704740..705111 + 372 WP_001169687.1 hypothetical protein -
CCF17_RS03780 (705132) 705132..705323 + 192 WP_001302048.1 hypothetical protein Antitoxin
CCF17_RS03785 (705325) 705325..705603 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCF17_RS25460 (706034) 706034..706192 - 159 WP_241201790.1 hypothetical protein -
CCF17_RS03795 (706242) 706242..706939 + 698 WP_225520032.1 IS1-like element IS1A family transposase -
CCF17_RS25465 (706943) 706943..707011 - 69 Protein_742 hypothetical protein -
CCF17_RS03800 (707104) 707104..707322 + 219 WP_032208669.1 protein YdfC -
CCF17_RS03805 (707326) 707326..707490 - 165 WP_001331716.1 hypothetical protein -
CCF17_RS03815 (707943) 707943..708640 + 698 WP_225520032.1 IS1-like element IS1A family transposase -
CCF17_RS03820 (708668) 708668..708856 + 189 WP_000449175.1 cell division inhibition protein DicB -
CCF17_RS03825 (708853) 708853..709041 + 189 WP_000199475.1 DUF1482 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T115485 WP_001303511.1 NZ_CP034212:705325-705603 [Escherichia albertii]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T115485 NZ_CP034212:705325-705603 [Escherichia albertii]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT115485 WP_001302048.1 NZ_CP034212:705132-705323 [Escherichia albertii]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT115485 NZ_CP034212:705132-705323 [Escherichia albertii]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References