Detailed information of TA system TA115462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE-RHH
• Location: 3898764..3899326
• Replicon: chromosome
• Accession: NZ_CP034179
• Organism: Novosphingobium tardaugens NBRC 16725

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U2YMP2
• Locus tag: EGO55_RS18380
• Protein ID: WP_021690667.1
• Coordinates: 3899033..3899326 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: U3A4T7
• Locus tag: EGO55_RS18375
• Protein ID: WP_021690668.1
• Coordinates: 3898764..3899033 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO55_RS18345	3893896..3894372	+	477	WP_040716090.1	hypothetical protein	-
EGO55_RS18350	3894407..3895546	+	1140	WP_052023713.1	phosphoadenosine phosphosulfate reductase family protein	-
EGO55_RS18355	3895611..3897299	+	1689	WP_040716087.1	ATP-binding protein	-
EGO55_RS18360	3897409..3897783	+	375	WP_124916881.1	hypothetical protein	-
EGO55_RS18365	3897780..3898307	+	528	WP_021690670.1	RES family NAD+ phosphorylase	-
EGO55_RS18370	3898360..3898566	+	207	WP_021690669.1	hypothetical protein	-
EGO55_RS18375	3898764..3899033	+	270	WP_021690668.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EGO55_RS18380	3899033..3899326	+	294	WP_021690667.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGO55_RS18385	3899401..3900561	+	1161	WP_210766570.1	hypothetical protein	-
EGO55_RS18390	3900643..3901143	+	501	WP_021690665.1	hypothetical protein	-
EGO55_RS18395	3901307..3901987	+	681	WP_040716233.1	NYN domain-containing protein	-
EGO55_RS18400	3902123..3902338	+	216	WP_040716230.1	hypothetical protein	-
EGO55_RS18405	3902866..3903198	+	333	WP_210766571.1	antibiotic biosynthesis monooxygenase	-
EGO55_RS18410	3903269..3904048	-	780	WP_021690661.1	enoyl-CoA hydratase/isomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Antitoxin ParD (3-81)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10775.35 Da
• Isoelectric Point: 5.6024

>T115462 WP_021690667.1 NZ_CP034179:3899033-3899326 [Novosphingobium tardaugens NBRC 16725]
MRLEFSPAANADLVEIASFIARDNVPRAVTFIDELETSCAQLVDFPHSGVARPELRVGLRSKPHESYVIFYSVLEQVIRI
ERILHGARDVGAILSPS

Nucleotide

• Length: 294 bp

>T115462 NZ_CP034179:3899033-3899326 [Novosphingobium tardaugens NBRC 16725]
ATGCGACTGGAATTTTCGCCCGCAGCGAATGCCGATCTTGTGGAGATCGCCAGCTTCATCGCTCGCGATAATGTCCCTCG
GGCTGTCACCTTCATCGACGAACTCGAAACGTCCTGCGCCCAGCTCGTCGATTTTCCCCATTCGGGCGTAGCCCGTCCCG
AGCTTCGTGTTGGACTACGATCCAAGCCGCACGAAAGCTATGTGATCTTCTACAGCGTTCTGGAGCAGGTCATCCGCATC
GAGCGTATCCTGCACGGTGCGCGCGACGTCGGCGCGATCCTTTCCCCAAGCTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9445.49 Da
• Isoelectric Point: 5.6643

>AT115462 WP_021690668.1 NZ_CP034179:3898764-3899033 [Novosphingobium tardaugens NBRC 16725]
MPSSFTLGAHFEGFIKSQVNSGRYASASEVVRDSLRLLEEQDAMRQARLDALRAEIEHGATSGPGIPADQAFANARKRIA
DIAAGAADS

Nucleotide

• Length: 270 bp

>AT115462 NZ_CP034179:3898764-3899033 [Novosphingobium tardaugens NBRC 16725]
ATGCCTTCCAGCTTCACTCTGGGCGCCCATTTCGAAGGTTTCATCAAGAGCCAGGTGAACAGCGGCCGCTATGCTTCGGC
CAGCGAAGTCGTGCGCGACAGCCTCCGGCTGCTCGAAGAGCAGGACGCTATGCGTCAGGCCCGGCTCGACGCGTTACGTG
CCGAGATCGAACATGGCGCCACCAGCGGTCCTGGCATTCCCGCCGATCAGGCTTTTGCGAACGCACGCAAGCGGATTGCC
GATATCGCCGCCGGCGCCGCGGATAGTTGA

Structures

Toxin

• AlphaFold DB: U2YMP2

Antitoxin

• AlphaFold DB: U3A4T7