Detailed information of TA system TA115457

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 769593..770152
• Replicon: chromosome
• Accession: NZ_CP034179
• Organism: Novosphingobium tardaugens NBRC 16725

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U2YAE2
• Locus tag: EGO55_RS03600
• Protein ID: WP_021691169.1
• Coordinates: 769593..769886 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EGO55_RS03605
• Protein ID: WP_021691170.1
• Coordinates: 769883..770152 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO55_RS03575	764991..767081	+	2091	WP_021691165.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
EGO55_RS03580	767078..767404	-	327	WP_210766632.1	DUF1905 domain-containing protein	-
EGO55_RS03590	767582..769204	-	1623	Protein_716	recombinase family protein	-
EGO55_RS03595	769223..769477	-	255	WP_021691168.1	hypothetical protein	-
EGO55_RS03600	769593..769886	-	294	WP_021691169.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGO55_RS03605	769883..770152	-	270	WP_021691170.1	ribbon-helix-helix domain-containing protein	Antitoxin
EGO55_RS03610	770616..772670	+	2055	WP_021691171.1	ParB/RepB/Spo0J family partition protein	-
EGO55_RS03615	773339..773638	+	300	WP_021691172.1	DUF736 domain-containing protein	-
EGO55_RS03620	773926..774765	+	840	WP_021691173.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11474.10 Da
• Isoelectric Point: 7.2779

>T115457 WP_021691169.1 NZ_CP034179:c769886-769593 [Novosphingobium tardaugens NBRC 16725]
MRIKWTGKASSDLVRLHEHLRPVAPEAAARVVQQLSRAPDRLLDYPRIGEKLDAYEPREVRRIIVGNYELRYEIADATIF
ILRLWHCREERSFESDD

Nucleotide

• Length: 294 bp

>T115457 NZ_CP034179:c769886-769593 [Novosphingobium tardaugens NBRC 16725]
ATGAGGATCAAGTGGACCGGCAAGGCGTCCTCGGATTTGGTGCGGCTGCACGAGCATCTGCGTCCGGTTGCCCCGGAGGC
GGCGGCGCGGGTCGTGCAGCAGCTCTCGCGCGCGCCGGATCGGCTGCTCGACTATCCCCGGATCGGCGAGAAGCTGGACG
CCTACGAGCCGCGCGAGGTTCGGCGCATCATCGTCGGCAATTACGAGCTGCGCTACGAGATTGCGGATGCGACGATCTTC
ATCCTGCGCCTGTGGCATTGCCGCGAGGAGCGCAGCTTCGAGTCGGACGACTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9914.26 Da
• Isoelectric Point: 5.1167

>AT115457 WP_021691170.1 NZ_CP034179:c770152-769883 [Novosphingobium tardaugens NBRC 16725]
MATETKVLTAHVPLHLAEKVEAMASRLERSRGWVMKQALAAWVDQEEERHRMTLEAMEDVDAGRVIDHQAVRAWADSLGT
DTPLPPPSA

Nucleotide

• Length: 270 bp

>AT115457 NZ_CP034179:c770152-769883 [Novosphingobium tardaugens NBRC 16725]
ATGGCGACTGAGACAAAAGTGTTGACCGCACACGTCCCGCTGCACCTCGCGGAGAAGGTTGAAGCAATGGCCTCGCGGCT
CGAACGCTCGCGTGGCTGGGTGATGAAACAGGCGCTCGCCGCCTGGGTTGATCAGGAGGAGGAGCGTCACCGCATGACGC
TCGAAGCAATGGAAGATGTCGATGCCGGGCGCGTGATCGACCATCAGGCCGTGCGCGCTTGGGCGGACAGCCTCGGCACT
GACACCCCGCTGCCGCCGCCTTCGGCATGA

Structures

Toxin

• AlphaFold DB: U2YAE2