Detailed information of TA system TA115452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1488488..1489075
• Replicon: chromosome
• Accession: NZ_CP034171
• Organism: Chryseobacterium taklimakanense strain H4753

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: EIH08_RS06930
• Protein ID: WP_124784682.1
• Coordinates: 1488776..1489075 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8WVU0
• Locus tag: EIH08_RS06925
• Protein ID: WP_055041555.1
• Coordinates: 1488488..1488772 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIH08_RS06905	1484349..1485649	+	1301	Protein_1367	IS5 family transposase	-
EIH08_RS06910	1485685..1486635	-	951	WP_124784680.1	hypothetical protein	-
EIH08_RS06915	1487236..1487760	-	525	WP_124784681.1	hypothetical protein	-
EIH08_RS12590	1487989..1488318	-	330	WP_164466710.1	hypothetical protein	-
EIH08_RS06925	1488488..1488772	-	285	WP_055041555.1	putative addiction module antidote protein	Antitoxin
EIH08_RS06930	1488776..1489075	-	300	WP_124784682.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EIH08_RS06935	1489518..1490429	+	912	WP_124784683.1	tyrosine-type recombinase/integrase	-
EIH08_RS06940	1490413..1491531	+	1119	WP_124784684.1	IS91 family transposase	-
EIH08_RS06950	1492069..1492304	-	236	Protein_1375	hypothetical protein	-
EIH08_RS06955	1492415..1493434	-	1020	WP_124784685.1	glycosyl hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Uncharacterized protein HI1420 (6-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11798.76 Da
• Isoelectric Point: 10.0546

>T115452 WP_124784682.1 NZ_CP034171:c1489075-1488776 [Chryseobacterium taklimakanense]
MYFIEKTNEFDKWFRKLKDIRAKAKILFRIQKLQNEEHFGDCKPVGNGISELRINFAKGYRIYFKETDGKIIILLIGGDK
SSQQKDIEKAKEIWEKIKE

Nucleotide

• Length: 300 bp

>T115452 NZ_CP034171:c1489075-1488776 [Chryseobacterium taklimakanense]
ATGTACTTTATTGAGAAAACAAATGAGTTTGACAAGTGGTTTCGAAAATTAAAAGATATCCGAGCAAAGGCTAAAATCTT
GTTCCGAATCCAGAAGTTACAAAACGAAGAACATTTTGGAGATTGCAAACCTGTTGGAAATGGAATCAGCGAATTGCGAA
TAAATTTTGCAAAGGGCTACAGAATCTATTTCAAAGAGACAGATGGAAAAATTATTATCTTGTTAATTGGCGGCGACAAA
TCAAGCCAACAAAAAGATATAGAAAAAGCGAAAGAAATTTGGGAAAAAATAAAAGAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10136.69 Da
• Isoelectric Point: 4.2958

>AT115452 WP_055041555.1 NZ_CP034171:c1488772-1488488 [Chryseobacterium taklimakanense]
MDISKFDIADYLDSNEMIAEYLNVVLEEGDDSEIVVAIGNIAKAIGMTKIAEETGMSRPSLYKALSEGAKPQFSTIMKVL
KAVGGQIRVNPITA

Nucleotide

• Length: 285 bp

>AT115452 NZ_CP034171:c1488772-1488488 [Chryseobacterium taklimakanense]
ATGGATATTTCAAAATTTGACATTGCAGATTATTTGGACAGCAACGAAATGATTGCTGAATATCTTAATGTTGTCCTTGA
AGAAGGCGATGATTCTGAAATTGTTGTAGCAATTGGTAATATTGCAAAAGCAATCGGAATGACAAAAATTGCAGAAGAAA
CAGGAATGAGCAGACCGAGTTTGTACAAAGCACTTTCTGAAGGTGCAAAACCACAGTTTTCAACAATTATGAAAGTTTTG
AAAGCAGTTGGCGGACAAATAAGAGTTAATCCTATAACTGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A3G8WVU0