Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 867601..868121 Replicon chromosome
Accession NZ_CP034170
Organism Nakamurella sp. s14-144

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag EH165_RS03765 Protein ID WP_124798093.1
Coordinates 867831..868121 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag EH165_RS03760 Protein ID WP_124798092.1
Coordinates 867601..867834 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH165_RS03740 862804..864282 - 1479 WP_124798088.1 DNA-3-methyladenine glycosylase 2 family protein -
EH165_RS03745 864495..865094 + 600 WP_206426177.1 methyltransferase domain-containing protein -
EH165_RS03750 865088..866362 + 1275 WP_164479113.1 DUF2029 domain-containing protein -
EH165_RS03755 866409..867488 + 1080 WP_124798091.1 redox-regulated ATPase YchF -
EH165_RS03760 867601..867834 + 234 WP_124798092.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
EH165_RS03765 867831..868121 + 291 WP_124798093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EH165_RS03770 868782..869039 + 258 WP_124798094.1 hypothetical protein -
EH165_RS03775 869186..869839 + 654 WP_124798095.1 SDR family NAD(P)-dependent oxidoreductase -
EH165_RS15635 869948..870718 - 771 WP_206426086.1 hypothetical protein -
EH165_RS03780 870866..872350 - 1485 Protein_749 amidohydrolase -
EH165_RS15640 872281..872523 - 243 WP_206426087.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11285.71 Da        Isoelectric Point: 6.7172

>T115451 WP_124798093.1 NZ_CP034170:867831-868121 [Nakamurella sp. s14-144]
VKSYRLTPAARQDLSSMWDFTQERWDSNQAEIYIFEIRAAIERIAADPLRGRACDEIPGQYRRYSIGSHLVFYVESTDSV
DVVRILHQRMDPTRHL

Download         Length: 291 bp

>T115451 NZ_CP034170:867831-868121 [Nakamurella sp. s14-144]
GTGAAGAGTTACCGCCTCACGCCGGCCGCGCGGCAAGATCTTTCATCGATGTGGGACTTCACTCAGGAGCGCTGGGATTC
CAACCAAGCCGAGATCTACATCTTCGAGATTAGGGCAGCGATCGAGCGGATCGCCGCTGATCCACTTCGAGGACGGGCGT
GCGACGAAATTCCTGGCCAGTACCGTCGCTACAGCATCGGTAGCCACTTGGTCTTTTACGTCGAGAGCACCGACAGTGTG
GACGTGGTCCGGATTCTGCACCAGCGGATGGATCCGACACGGCACTTATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8468.30 Da        Isoelectric Point: 4.2340

>AT115451 WP_124798092.1 NZ_CP034170:867601-867834 [Nakamurella sp. s14-144]
MAQNTSISLDDHFASFLSREVATGRYRSASEVVRAALRLLEDQEAQMAALRGALVAGEESGAPEEFDFDEFVESKRS

Download         Length: 234 bp

>AT115451 NZ_CP034170:867601-867834 [Nakamurella sp. s14-144]
ATGGCGCAAAACACCTCAATCAGCTTGGACGACCACTTCGCAAGCTTCCTCTCCCGTGAAGTCGCGACCGGACGGTACCG
GTCTGCCAGCGAAGTCGTCCGCGCCGCCCTGAGGTTGCTGGAAGATCAGGAAGCGCAGATGGCGGCGCTCAGGGGCGCAT
TAGTAGCTGGCGAAGAGAGCGGTGCACCGGAAGAGTTCGACTTCGACGAGTTTGTAGAGTCGAAGAGGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References