115449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 74700..75837 Replicon plasmid unnamed
Accession NZ_CP034168
Organism Enterococcus avium strain 352

Toxin (Protein)


Gene name zeta Uniprot ID A0A4P8K9G6
Locus tag EH197_RS00410 Protein ID WP_071621496.1
Coordinates 74974..75837 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag EH197_RS00405 Protein ID WP_000301765.1
Coordinates 74700..74972 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH197_RS00380 70947..71759 + 813 WP_137438809.1 AAA family ATPase -
EH197_RS00385 71924..72604 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
EH197_RS00390 72661..73377 + 717 Protein_78 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
EH197_RS00395 73473..74369 + 897 WP_118368339.1 ParA family protein -
EH197_RS00400 74474..74683 + 210 WP_000527317.1 peptide-binding protein -
EH197_RS00405 74700..74972 + 273 WP_000301765.1 antitoxin Antitoxin
EH197_RS00410 74974..75837 + 864 WP_071621496.1 zeta toxin family protein Toxin
EH197_RS00415 76281..76961 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
EH197_RS00420 77146..77754 + 609 Protein_84 IS256-like element IS256 family transposase -
EH197_RS00425 77884..79323 - 1440 WP_001028144.1 aminoglycoside O-phosphotransferase APH(2'')-Ia -
EH197_RS00430 79324..79626 - 303 Protein_86 GNAT family N-acetyltransferase -
EH197_RS00435 79681..80361 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
EH197_RS00440 80684..80767 + 84 Protein_88 peptide-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') / erm(B) - 1..87704 87704
- inside IScluster/Tn aac(6')-aph(2'') / erm(B) - 71918..81761 9843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32445.01 Da        Isoelectric Point: 6.6610

>T115449 WP_071621496.1 NZ_CP034168:74974-75837 [Enterococcus avium]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

>T115449 NZ_CP034168:74974-75837 [Enterococcus avium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGTTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT115449 WP_000301765.1 NZ_CP034168:74700-74972 [Enterococcus avium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT115449 NZ_CP034168:74700-74972 [Enterococcus avium]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8K9G6

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References